PMID: 8584471Oct 1, 1995Paper

Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier

Pharmaceutical Research
B V Zlokovic

Abstract

The study of peptide transport across the blood-brain barrier (BBB) is a field fraught with conflicting interpretations. This review presents a fairly strong case that peptides can be differentially transported at the BBB. However, minimal transport of peptides could have important impact on central nervous system (CNS) functions since only small amounts are needed for physiologic pharmacologic and/or pathologic effects. Several BBB peptide transport mechanisms (i.e., receptor-mediated, absorptive-mediated, carrier-mediated and non-specific passive diffusion), as well as non-transport processes (i.e., endocytosis without transcytosis, absorption and metabolism) are discussed. It is emphasized that peptide transport systems at the BBB could be important targets for both therapeutic delivery of peptides and the development of certain brain pathologies. Strategies to manipulate peptide BBB transport processes have been discussed including lipidization, chemical modifications of the N-terminal end, coupling of transport with post-BBB metabolism and formation of potent neuroactive peptides, up-regulation of putative peptide transporters, use of chimeric peptides in which non-transportable peptide is chemically linked to a transporta...Continue Reading

Citations

Dec 1, 2001·Expert Opinion on Biological Therapy·J TemsamaniJ M Scherrmann
Apr 6, 2006·The AAPS Journal·Ken A Witt, Thomas P Davis
Feb 29, 2008·The Journal of Pharmacology and Experimental Therapeutics·Tracy A BrooksThomas P Davis
May 31, 2011·Expert Opinion on Drug Delivery·Francesca MalerbaAntonino Cattaneo
Aug 1, 2002·Current Protocols in Pharmacology·Kathleen M K Boje
Jul 22, 2015·Nature Reviews. Neurology·Jenna M Tarasoff-ConwayMony J de Leon
May 27, 2016·Nature Neuroscience·Melanie D SweeneyBerislav V Zlokovic
Mar 12, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew R HallidayBerislav V Zlokovic
Nov 12, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Franciska ErdőElizabeth de Lange
Jun 15, 2000·Journal of Neurochemistry·A NovotnyR F Keep
Aug 3, 1999·Nature Biotechnology·M J During, C G Janson
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Hidekazu ToyobukuAkira Tsuji
Apr 23, 2008·Current Protocols in Neuroscience·K M Boje
Apr 18, 2008·The Journal of Pharmacy and Pharmacology·Matthias BrandschEva Bosse-Doenecke
Apr 3, 2016·Acta Neuropathologica·Axel MontagneBerislav V Zlokovic
Apr 23, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Melanie D SweeneyBerislav V Zlokovic
May 6, 2015·Expert Review of Neurotherapeutics·Alison BurgessKullervo Hynynen
Jul 5, 2017·Cell Research·Zhen Zhao, Berislav V Zlokovic
Jan 25, 2018·International Journal of Molecular Sciences·Botond PenkeLászló Vígh
Jan 17, 2017·Scientific Reports·Ken MatobaToshihide Yamashita
Nov 20, 2019·Cognitive Neurodynamics·Junyang WangUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 24, 2002·Endocrinology·Hideki TamuraShinichi Oikawa
Oct 1, 2010·Expert Opinion on Drug Discovery·Mellar P Davis
Jun 17, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Samuel R BarnesRussell E Jacobs
Jun 20, 2014·Brain Pathology·Ethan A WinklerBerislav V Zlokovic
Apr 26, 2017·The EMBO Journal·Simonetta Camandola, Mark P Mattson
Aug 22, 2017·The Journal of Clinical Investigation·Mariko KurodaToshihide Yamashita
Mar 5, 2016·Frontiers in Neuroscience·Katerina AkassoglouBerislav V Zlokovic
Nov 18, 2020·Drug Discovery Today·Diogo C FernandesJ Miguel Oliveira
Nov 20, 2020·Fluids and Barriers of the CNS·Hossam KadryLuca Cucullo

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