Cerebrovascular Reactivity and Central Arterial Stiffness in Habitually Exercising Healthy Adults

Frontiers in Physiology
Kathleen B MillerJill N Barnes

Abstract

Reduced cerebrovascular reactivity to a vasoactive stimulus is associated with age-related diseases such as stroke and cognitive decline. Habitual exercise is protective against cognitive decline and is associated with reduced stiffness of the large central arteries that perfuse the brain. In this context, we evaluated the age-related differences in cerebrovascular reactivity in healthy adults who habitually exercise. In addition, we sought to determine the association between central arterial stiffness and cerebrovascular reactivity. We recruited 22 young (YA: age = 27 ± 5 years, range 18-35 years) and 21 older (OA: age = 60 ± 4 years, range 56-68 years) habitual exercisers who partake in at least 150 min of structured aerobic exercise each week. Middle cerebral artery velocity (MCAv) was recorded using transcranial Doppler ultrasound. In order to assess cerebrovascular reactivity, MCAv, end-tidal carbon dioxide (ETCO2), and mean arterial pressure (MAP) were continuously recorded at rest and during stepwise elevations of 2, 4, and 6% inhaled CO2. Cerebrovascular conductance index (CVCi) was calculated as MCAv/MAP. Central arterial stiffness was assessed using carotid-femoral pulse wave velocity (PWV). Older adults had higher P...Continue Reading

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Citations

Nov 5, 2019·Frontiers in Aging Neuroscience·Kathleen B MillerJill N Barnes
Dec 20, 2018·Brain Plasticity·Jill N Barnes, Adam T Corkery
Aug 10, 2019·American Journal of Physiology. Heart and Circulatory Physiology·R Matthew BrothersDavid M Keller
Mar 15, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Bernard ChoiMark J Fisher
Apr 6, 2021·Frontiers in Physiology·Venkatagiri KrishnamurthyJoe R Nocera
May 7, 2021·Journal of the International Neuropsychological Society : JINS·Jill N BarnesKathleen B Miller
Mar 12, 2021·Journal of Applied Physiology·Mohammed R AlwatbanSandra A Billinger
Jun 1, 2021·Frontiers in Physiology·Larissa McKettonDavid J Mikulis
Apr 23, 2021·Journal of Applied Physiology·Adam T CorkeryJill N Barnes

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