Cerebrovascular reactivity in patients with ruptured intracranial aneurysms

Journal of Neurosurgery
B VoldbyF T Jensen

Abstract

The cerebral vasomotor reactivity to arterial hypotension and hypocapnia was studied in 34 patients between the 3rd and 13th day after rupture of an intracranial saccular aneurysm. Using the intra-arterial xenon-133 injection method, regional cerebral blood flow (rCBF) and cerebral metabolic rate of oxygen (CMRO2) were measured. The intraventricular pressure and cerebrospinal fluid (CSF) lactate and pH levels were determined. The degree of vasospasm was measured on angiograms taken immediately following the rCBF study. The patients were graded clinically according to the system of Hunt and Hess. Cerebral autoregulation was intact in patients in good clinical condition, but was impaired in patients in poor clinical condition. There was a close correlation between the degree of vasospasm and the degree of autoregulatory impairment, which varied from focal disturbances to global impairment. Intracranial hypertension and CSF lactic acidosis were commonly found in association with vasoparalysis. Cerebrovascular response to hyperventilation was generally preserved, although often reduced. During hyperventilation, the cerebral perfusion pressure became elevated, and increases in CMRO2 were often found, even in patients with severe dif...Continue Reading

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Related Concepts

Cerebral Blood Flow Imaging
Subarachnoid Hemorrhage, Spontaneous
Lactate
Aneurysm
Brain
Vasospasm, Intracranial
Vasospasm
Cerebrospinal Fluid
Intracranial Aneurysm
Lactic Acid Measurement

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