Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI

Journal of Magnetic Resonance Imaging : JMRI
Domenico ZacáJay J Pillai

Abstract

(i) to validate blood oxygenation level dependent (BOLD) breathhold cerebrovascular reactivity (BH CVR) mapping as an effective technique for potential detection of neurovascular uncoupling (NVU) in a cohort of patients with perirolandic low grade gliomas undergoing presurgical functional MRI (fMRI) for sensorimotor mapping, and (ii) to determine whether NVU potential, as assessed by BH CVR mapping, is prevalent in this tumor group. We retrospectively evaluated 12 patients, with histological diagnosis of grade II glioma, who performed multiple motor tasks and a BH task. Sensorimotor activation maps and BH CVR maps were compared in two automatically defined regions of interest (ROIs), ipsilateral to the lesion (i.e., ipsilesional) and contralateral to the lesion (i.e., contralesional). Motor task mean T-value was significantly higher in the contralesional ROIs (6.00 ± 1.74 versus 4.34 ± 1.68; P = 0.00004) as well as the BH mean T-value (4.74 ± 2.30 versus 4.09 ± 2.50; P = 0.009). The number of active voxels was significantly higher in the contralesional ROIs (Z = 2.99; P = 0.03). Actual NVU prevalence was 75%. Presurgical sensorimotor fMRI mapping can be affected by NVU-related false negative activation in low grade gliomas (76%...Continue Reading

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Citations

Dec 3, 2014·Neuroimaging Clinics of North America·Domenico ZacàJay J Pillai
Jul 24, 2015·Journal of Magnetic Resonance Imaging : JMRI·Shruti AgarwalJay J Pillai
Aug 8, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Amir IranmahboobAndrei I Holodny
Jul 16, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Paul D BaileyJay J Pillai
Jul 6, 2014·BioMed Research International·Meng Yue TangXiao Hua Huang
Jun 3, 2015·Journal of Neuroradiology. Journal De Neuroradiologie·Naïla BoudiafAlexandre Krainik
Feb 27, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jorn FierstraOliver Bozinov
May 3, 2014·AJNR. American Journal of Neuroradiology·J J Pillai, D J Mikulis
May 12, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rebecca W PakArvind P Pathak
Apr 2, 2017·AJNR. American Journal of Neuroradiology·N Yahyavi-Firouz-AbadiH I Sair
Jan 27, 2018·AJNR. American Journal of Neuroradiology·S G BowdenJ Grinband
Aug 25, 2018·Brain Connectivity·Michelle E Fox, Tricia Z King
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Aug 14, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Andreas StadlbauerSebastian Brandner
Mar 23, 2017·Human Brain Mapping·Pedro Lima CardosoSimon Daniel Robinson
Aug 24, 2017·Current Treatment Options in Neurology·Antonella CastellanoAndrea Falini
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Apr 10, 2020·Topics in Magnetic Resonance Imaging : TMRI·Seyed Ali NabavizadehRonald L Wolf
Feb 5, 2021·Frontiers in Physiology·Joana PintoPatrícia Figueiredo
Apr 17, 2019·Journal of Neuroscience Methods·Henning U VossAndrei I Holodny
Mar 16, 2021·Frontiers in Physiology·Emilie SleightMichael J Thrippleton
Jul 3, 2021·Neuro-oncology·Petros D PetridisJack Grinband
Apr 12, 2020·NeuroImage·Peiying LiuHanzhang Lu
Nov 27, 2016·NeuroImage·Peiying LiuHanzhang Lu

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