Cerebrovascular response in infants and young children following severe traumatic brain injury: a preliminary report

Pediatric Neurosurgery
P D AdelsonH Yonas

Abstract

To further describe the pathophysiologic processes that occur in infants and young children after severe traumatic brain injury (TBI), we retrospectively reviewed the cerebral blood flow (CBF) values and 6-month Glasgow Outcome Scores (GOS) in 30 children < or = 8 years old (25 were < or = 4 years old) with a Glasgow Coma Score (GCS) on admission of < or = 8. Twelve females and 18 males (mean age 2.1 years, range 1 month to 8 years) underwent 61 CBF studies using stable xenon computed tomography at variable times from admission to 9 days after TBI. In 12 patients, PaCO2 was manipulated an average of 8.4 torr (range 5-11 torr) and a second CBF study performed to determine CO2 vasoreactivity (CO2VR), defined as the percent change in CBF per torr change in PaCO2. CBF on admission (n = 13)was 25.1+/-7.7 ml/100 g/min (mean +/- SEM) and was < or = 20 ml/100 g/min in 10 of 13 patients (77%). By 24 h and for up to 6 days after TBI, the mean CBF increased to 55.3+/-3.4 ml/100 g/min (range 2-95) which differed significantly from the admission CBF value (p < 0.05); a CBF of >70 ml/100 g/min tended to be associated with a good outcome. Poor outcome (GOS < or = 3) was seen uniformly in children under the age of 1 year and in patients with a...Continue Reading

Citations

Sep 30, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K S HendrichC Ho
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alina TudoricaGeorge C Newman
Nov 26, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ursula K Rohlwink, Anthony A Figaji
Nov 26, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Anthony A Figaji
May 12, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·P David AdelsonPatrick M Kochanek
Dec 21, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Sarah Murphy
Nov 10, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·C VuillaumeT Geeraerts
Mar 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Mathew B PottsLinda J Noble-Haeusslein
Jan 21, 2006·Journal of Neuroradiology. Journal De Neuroradiologie·M WintermarkH Yonas
Sep 23, 1998·Pediatric Neurology·E E Gilles, M D Nelson
Oct 28, 2003·Journal of Neurotrauma·Ajai K MalhotraKenneth G Proctor
Dec 28, 2007·Journal of Neurotrauma·Rachel Pardes BergerP David Adelson
Mar 11, 2009·Journal of Neurotrauma·P David Adelson
Mar 23, 2012·Journal of Neurotrauma·William M ArmsteadAbd Al-Roof Higazi
Jul 22, 1998·Critical Care Medicine·R S Clark, P M Kochanek
May 16, 2000·Critical Care Medicine·M J WhalenP D Adelson
Jan 17, 2003·Critical Care Medicine·Catherine A Mazzola, P David Adelson
Aug 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M J WhalenP M Kochanek
Jun 10, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Yong Y HanPatrick M Kochanek
Mar 27, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Augusto PérezCarlos A Ciraolo
Jul 9, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·P David AdelsonUNKNOWN World Federation of Pediatric Intensive and Critical Care Societies
Jul 9, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·P David AdelsonUNKNOWN World Federation of Pediatric Intensive and Critical Care Societies
May 15, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Rebecca CurryMonica S Vavilala
Aug 17, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·I R ChambersR A Minns
Aug 2, 2011·Neurological Research·William M Armstead, Ramesh Raghupathi
Jul 18, 2014·PloS One·W Alan C MutchLawrence Ryner
Jun 3, 2010·Journal of Neurosurgery. Pediatrics·Paul H LeliefeldL Jaap Kappelle
May 18, 2006·Journal of Neurosurgery·Anthony MarmarouM Ross Bullock
Sep 2, 2008·Journal of Neurosurgery. Pediatrics·Paul H LeliefeldPatrick W Hanlo
Jan 29, 2002·American Journal of Ophthalmology·Valérie BiousseScott R Lambert
Aug 19, 2014·Journal of Neurotrauma·Amy C ClevengerSusan S Margulies
May 26, 2009·Developmental Neurorehabilitation·Emilie GuettardMathilde P Chevignard

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