Abstract
Cerebral blood flow (CBF) responsiveness to alterations in arterial CO2 tensions (PaCO2) during 1.4% and 2.8% isoflurane anesthesia was assessed. Dogs were initially anesthetized with thiopental (12 mg/kg, iv bolus), their tracheae intubated, after which anesthesia was maintained with 1.4% isoflurane. In eight animals three levels of PaCO2 (25, 40, and 60 mmHg) were studied during 1.4% and 2.8% isoflurane. Mean arterial blood pressure, sagittal sinus pressure, and cerebrospinal fluid pressure were measured and CBF was determined using radiolabeled microspheres. Cerebral perfusion pressure (CPP) was maintained constant at approximately 80 mmHg by inflation of a balloon in the midthoracic aorta. CBF during normocapnia was 70 +/- 14 and 118 +/- 18 ml.min-1.100 g-1 with 1.4% and 2.8% isoflurane, respectively. As PaCO2 was decreased and increased, CBF decreased and increased to 42 +/- 7% and 185 +/- 16% of control, respectively, during 1.4% isoflurane. During 2.8% isoflurane, hypocapnia decreased CBF to 39 +/- 6% of control, but CBF did not increase with hypercapnia. In a second group of animals (n = 8), the effects of changes in CPP during hypercapnia with 1.4% and 2.8% isoflurane were assessed. Increasing CPP approximately 25 mmHg...Continue Reading
Citations
Feb 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B Bisonnette, J E Leon
Feb 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T NishiyamaK Hanaoka
Oct 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J E Leon, B Bissonnette
May 27, 2008·Journal of Anesthesia·Yuji KadoiKen-ichiro Takahashi
Jun 2, 2010·Journal of Anesthesia·Hiroshi HinoharaAkio Mizutani
Aug 18, 2006·British Journal of Anaesthesia·P E TanskanenR E Aantaa
Sep 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·J PatelA D Edwards
Aug 29, 2000·Anesthesia and Analgesia·W E Hoffman, G Edelman
Jun 23, 2006·Anesthesia and Analgesia·Yuji KadoiFumio Goto
Aug 21, 2001·CNS Drugs·P Ravussin, O Wilder-Smith
Jan 10, 2003·American Journal of Veterinary Research·Robert J BrosnanGregg D Kortz
Feb 22, 2014·Anesthesia and Analgesia·George J CrystalM Ramez Salem
Dec 6, 2001·Journal of Neurosurgical Anesthesiology·W E HoffmanZ S Jonjev
Apr 25, 2000·Journal of Neurosurgical Anesthesiology·W E Hoffman, G Edelman
Mar 17, 2004·Journal of Neurosurgical Anesthesiology·Anders Holmström, J Akeson
Aug 5, 1999·Journal of Computer Assisted Tomography·D G NabaviT Y Lee
May 30, 1998·Anesthesiology·J E Brian
Apr 30, 2003·Anesthesiology·Marcial FragaJavier Belda
Feb 28, 2003·Anesthesiology·Shin InabaTakashi Nishino
Jun 29, 2011·NeuroImage·Renata F LeoniAfonso C Silva
May 26, 2009·Journal of Clinical Anesthesia·Yuji KadoiKenichiro Takahashi
Aug 24, 2007·Acta Anaesthesiologica Scandinavica·Y KadoiK Takahashi
Feb 27, 2013·Veterinary Anaesthesia and Analgesia·Attila Arany-TóthTibor Németh
May 20, 1999·The Veterinary Clinics of North America. Small Animal Practice·C E Short, A Bufalari
Jul 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J M Gidday, T S Park
Feb 11, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Pascale Schumann-BardEric A Schmidt
Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·M A HelfaerR J Traystman
Dec 10, 1999·Anesthesia and Analgesia·T NishiyamaK Hanaoka
Feb 24, 2011·Physiological Measurement·Matthew J MurphyTing-Yim Lee
Jun 29, 2001·Anesthesia and Analgesia·W E HoffmanH M Koenig
Aug 18, 2009·Anaesthesia and Intensive Care·Y KadoiA Mizutani
Mar 18, 2004·Acta Anaesthesiologica Scandinavica·A HolmströmJ Akeson