PMID: 2497663May 1, 1989Paper

Cerebrovascular responsiveness to carbon dioxide in dogs with 1.4% and 2.8% isoflurane

Anesthesiology
R W McPhersonR J Traystman

Abstract

Cerebral blood flow (CBF) responsiveness to alterations in arterial CO2 tensions (PaCO2) during 1.4% and 2.8% isoflurane anesthesia was assessed. Dogs were initially anesthetized with thiopental (12 mg/kg, iv bolus), their tracheae intubated, after which anesthesia was maintained with 1.4% isoflurane. In eight animals three levels of PaCO2 (25, 40, and 60 mmHg) were studied during 1.4% and 2.8% isoflurane. Mean arterial blood pressure, sagittal sinus pressure, and cerebrospinal fluid pressure were measured and CBF was determined using radiolabeled microspheres. Cerebral perfusion pressure (CPP) was maintained constant at approximately 80 mmHg by inflation of a balloon in the midthoracic aorta. CBF during normocapnia was 70 +/- 14 and 118 +/- 18 ml.min-1.100 g-1 with 1.4% and 2.8% isoflurane, respectively. As PaCO2 was decreased and increased, CBF decreased and increased to 42 +/- 7% and 185 +/- 16% of control, respectively, during 1.4% isoflurane. During 2.8% isoflurane, hypocapnia decreased CBF to 39 +/- 6% of control, but CBF did not increase with hypercapnia. In a second group of animals (n = 8), the effects of changes in CPP during hypercapnia with 1.4% and 2.8% isoflurane were assessed. Increasing CPP approximately 25 mmHg...Continue Reading

Citations

Feb 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B Bisonnette, J E Leon
Feb 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T NishiyamaK Hanaoka
Oct 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J E Leon, B Bissonnette
Sep 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·J PatelA D Edwards
Aug 29, 2000·Anesthesia and Analgesia·W E Hoffman, G Edelman
Aug 21, 2001·CNS Drugs·P Ravussin, O Wilder-Smith
Jan 10, 2003·American Journal of Veterinary Research·Robert J BrosnanGregg D Kortz
Feb 22, 2014·Anesthesia and Analgesia·George J CrystalM Ramez Salem
Dec 6, 2001·Journal of Neurosurgical Anesthesiology·W E HoffmanZ S Jonjev
Apr 25, 2000·Journal of Neurosurgical Anesthesiology·W E Hoffman, G Edelman
May 30, 1998·Anesthesiology·J E Brian
Feb 27, 2013·Veterinary Anaesthesia and Analgesia·Attila Arany-TóthTibor Németh
May 20, 1999·The Veterinary Clinics of North America. Small Animal Practice·C E Short, A Bufalari
Jul 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J M Gidday, T S Park
Feb 11, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Pascale Schumann-BardEric A Schmidt
Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·M A HelfaerR J Traystman
Feb 24, 2011·Physiological Measurement·Matthew J MurphyTing-Yim Lee
Mar 18, 2004·Acta Anaesthesiologica Scandinavica·A HolmströmJ Akeson

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.