Cerium Oxide Nanoparticle Effects on Paraoxonase-1 Activity and Oxidative Toxic Stress Induced by Malathion: A Potential Antioxidant Compound, Yes or No?

Indian Journal of Clinical Biochemistry : IJCB
Seyed Abdolhakim HosseiniAkram Ranjbar

Abstract

Cerium oxide nanoparticles (CeNPs) are one of the most widely used and important nanoparticles in addition to possessing strong antioxidative properties and inhibiting free radicals. Paraoxonase-1 (PON1) is one of the enzymes that protect the body against damage caused by oxidative stress. The purpose of this study was to investigate the effect of CeNPs on the activity of PON1 as well as biomarkers of oxidative stress in the toxicity of malathion. 48 Albino Wistar male rats with weight range of 180-250 g were randomly divided into 8 groups, Group 1: healthy control, injection of normal saline, Group 2: administration by the malathion 100 mg/kg/day, Group 3: treated with CeNPs 15 mg/kg/day, Group 4: treated with CeNPs 30 mg/kg/day, Group 5: combination of malathion with dose of 100 mg/kg/day and CeNPs 15 mg/kg, Group 6: combination of malathion with dose of 100 mg/kg/day and CeNPs 30 mg/kg for 14 days and 24 h after termination of treatment period, serum and liver tissue samples were collected from all rats. Biochemical test of PON1 activity, oxidative stress biomarkers including total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), were carried out. Malathion reduced plasma TTG levels, TAC and in...Continue Reading

References

Mar 18, 2008·Basic & Clinical Pharmacology & Toxicology·Rafael TrevisanAlcir L Dafre
Mar 3, 2010·Human & Experimental Toxicology·Akram RanjbarMohammad Abdollahi
Jul 1, 2005·Environmental Toxicology and Pharmacology·Akram RanjbarMohammad Abdollahi
Mar 1, 2007·Environmental Toxicology and Pharmacology·F P PossamaiF Dal-Pizzol
Mar 1, 2012·Toxicology·Michael EddlestonR Eddie Clutton
Sep 19, 2012·Skin Pharmacology and Physiology·R RamadanD Tawfik
Jan 25, 2013·Toxicology and Industrial Health·Slimen SelmiNajoua Gharbi
May 22, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Antonio F HernándezRaquel Alarcón
Nov 19, 2014·Environmental Science and Pollution Research International·Raja RezgNajoua Gharbi
Dec 3, 2014·Chemico-biological Interactions·Volodymyr I Lushchak
Jul 15, 2015·Environmental Science and Pollution Research International·Imen Flehi-SlimHassen Ben Cheikh
Oct 11, 2015·Pesticide Biochemistry and Physiology·Ines El-Bini DhouibSaloua El-Fazaa
Oct 23, 2015·Scientific Reports·Gerardo Pulido-ReyesFrancisca Fernández-Piñas
Dec 19, 2015·Physiological Reviews·Xin Gen LeiElias S J Arnér
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Anton L PopovVladimir K Ivanov
Nov 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ebrahim ZarrinkalamAlireza Komaki

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.