Certain norditerpenoid alkaloids and their cardiovascular action

Journal of Natural Products
H K DesaiS W Pelletier

Abstract

Thirteen new derivatives of norditerpenoid alkaloids, namely, 8-deacetyl-8-p-aminobenzoyldelphinine (1), 8-deacetyl-8-anthranoyldelphinine (2), 8-deacetyl-8-(4-hydroxy-3-methoxycinnamoyl)delphinine (3), 16-demethoxy-15,16-didehydro-8-p-anisoyl-14-benzoyldelpho nine (4), 6-acetylheteratisine N-oxide (6), 3,8-diacetylfalconerine (7), 8-stearoylfalconerine (8), 8-linolenylfalconerine (9), 13-acetylpyrodelphinine (11), 13-acetyldelphinine N-oxide (13), N-deacetyl-8,9-diacetyllappaconitine (14), 8, 9-(methylenedioxy)lappaconine (15), and 16-epipyroaconitine N-oxide (17), were prepared, and their structures were established by analysis of spectroscopic data (1D and 2D NMR, HRFABMS). The preliminary in vivo cardiovascular action (hypotensive, bradycardic, and ventricular arrhythmias) of these new compounds was tested in male Sprague-Dawley rats. The results are reported herein.

References

Sep 5, 1995·European Journal of Pharmacology·H ChiaoR W Caldwell

❮ Previous
Next ❯

Citations

Jan 28, 2005·International Journal of Legal Medicine·J BeikeH Köhler
Jan 18, 2013·Journal of Asian Natural Products Research·Sai-Yang ZhangYan-Bing Zhang
Sep 15, 2005·Natural Product Research· Atta-ur-RahmanM Iqbal Choudhary
Jul 15, 2011·Acta Crystallographica. Section E, Structure Reports Online·Yan MuSong-Qing Hu
Jun 20, 2001·Chemical & Pharmaceutical Bulletin·F P WangB G Li
Oct 20, 2015·The American Journal of Chinese Medicine·Pengcheng WangHaixue Kuang
Mar 26, 2010·Natural Product Reports·Feng-Peng WangXiao-Yu Liu
Aug 24, 2010·Journal of Separation Science·Wenlong LiuShuying Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Journal of Asian Natural Products Research
F P WangD L Chen
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Liang XiongQin-Mei Zhou
© 2022 Meta ULC. All rights reserved