Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients

Antioxidants
M A DubickJames L Atkins

Abstract

Normal iron handling appears to be disrupted in critically ill patients leading to hypoferremia that may contribute to systemic inflammation. Ceruloplasmin (Cp), an acute phase reactant protein that can convert ferrous iron to its less reactive ferric form facilitating binding to ferritin, has ferroxidase activity that is important to iron handling. Genetic absence of Cp decreases iron export resulting in iron accumulation in many organs. The objective of this study was to characterize iron metabolism and Cp activity in burn and non-burn trauma patients to determine if changes in Cp activity are a potential contributor to the observed hypoferremia. Under Brooke Army Medical Center Institutional Review Board approved protocols, serum or plasma was collected from burn and non-burn trauma patients on admission to the ICU and at times up to 14 days and measured for indices of iron status, Cp protein and oxidase activity and cytokines. Burn patients showed evidence of anemia and normal or elevated ferritin levels. Plasma Cp oxidase activity in burn and trauma patients were markedly lower than controls on admission and increased to control levels by day 3, particularly in burn patients. Plasma cytokines were elevated throughout the 1...Continue Reading

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Citations

Nov 30, 2018·International Journal of Environmental Research and Public Health·Susana Rivera-MancíaJosé Pedraza-Chaverri
Mar 13, 2021·Oxidative Medicine and Cellular Longevity·Krzysztof GwozdzinskiLukasz Gwozdzinski

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Methods Mentioned

BETA
electron spin resonance
ELISA
ISS

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