Ceruloplasmin plasma levels in patients with severe forms of herpes infection

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Irina Novikova, Maria Zlotnikova

Abstract

Research interest in ceruloplasmin (CP) has significantly increased in recent years owing to new discoveries of its properties including anti-inflammatory and anti-oxidant effects. Data on CP blood plasma level in patients with herpetic infection caused by herpes simplex virus are scarce and often contradictory. Most point to a reduction of CP in the blood plasma of patients during the exacerbation of the disease with gradually return to normal values after treatment. There is evidence of an increase in CP levels during the acute period of CRHI (chronic recurrent herpes infection) and decrease in remission. The content of ceruloplasmin in blood plasma was determined by immunoturbidimetry using the test-systems "Spinreact" (Spain) and biochemical analyzer "Architect C8000". We found that in patients with severe forms of chronic recurrent herpes infection in the exacerbation period, CP levels were increased by approximately 35% relative to the control values. However in the remission period in 80% of patients, CP concentrations remained elevated and in some patients the CP level was even increased in comparison with values in the exacerbation. Such dynamics of CP were not caused by the exacerbation of concomitant diseases. The in...Continue Reading

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Citations

Jan 23, 2016·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Angelique N BesoldValeria C Culotta
Jul 25, 2012·Free Radical Biology & Medicine·Douglas GaniniMaria B Kadiiska
Jan 13, 2015·Biological Trace Element Research·Necmettin AktepeHakim Celik
Oct 31, 2014·Infection·R SoundravallyC C Cleetus

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