Cervical Adenocarcinomas: A Heterogeneous Group of Tumors With Variable Etiologies and Clinical Outcomes

Archives of Pathology & Laboratory Medicine
Anjelica Hodgson, Kay J Park

Abstract

Cervical adenocarcinomas are a heterogeneous group of tumors with varying morphologies, etiologies, molecular drivers, and prognoses, comprising approximately 25% of all cervical cancers. Unlike cervical squamous cell carcinoma, adenocarcinomas are not uniformly caused by high-risk human papillomavirus (HPV) infection and, therefore, would not necessarily be prevented by the HPV vaccine. To provide a review of endocervical adenocarcinoma subtypes and, when appropriate, discuss precursor lesions, etiologies, molecular genetics, and ancillary studies within the context of clinical care. Some historical perspectives will also be provided. Data sources included published peer-reviewed literature and personal experiences of the senior author. Endocervical adenocarcinomas are a histologically diverse group of tumors with various causes and molecular drivers, not all related to HPV infection. Distinguishing them has important implications for treatment and prognosis as well as strategies for prevention.

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Citations

Jan 8, 2020·The Medical Journal of Australia·Julia Ml BrothertonMarion Saville
Jul 24, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Richard Wing-Cheuk WongPhilip P C Ip
Jul 10, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eunhyang ParkNam Hoon Cho
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Oct 29, 2020·Der Pathologe·Irena Baltisser
Dec 17, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Nalee KimYoung Seok Cho

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