Cervical Cancer: Associations between Metabolic Parameters and Whole Lesion Histogram Analysis Derived from Simultaneous 18 F-FDG-PET/MRI

Contrast Media & Molecular Imaging
Hans-Jonas MeyerAlexey Surov

Abstract

Multimodal imaging has been increasingly used in oncology, especially in cervical cancer. By using a simultaneous positron emission (PET) and magnetic resonance imaging (MRI, PET/MRI) approach, PET and MRI can be obtained at the same time which minimizes motion artefacts and allows an exact imaging fusion, which is especially important in anatomically complex regions like the pelvis. The associations between functional parameters from MRI and 18F-FDG-PET reflecting different tumor aspects are complex with inconclusive results in cervical cancer. The present study correlates histogram analysis and 18F-FDG-PET parameters derived from simultaneous FDG-PET/MRI in cervical cancer. Overall, 18 female patients (age range: 32-79 years) with histopathologically confirmed squamous cell cervical carcinoma were retrospectively enrolled. All 18 patients underwent a whole-body simultaneous 18F-FDG-PET/MRI, including diffusion-weighted imaging (DWI) using b-values 0 and 1000 s/mm2. Apparent diffusion coefficient (ADC) histogram parameters included several percentiles, mean, min, max, mode, median, skewness, kurtosis, and entropy. Furthermore, mean and maximum standardized uptake values (SUVmean and SUVmax), metabolic tumor volume (MTV), and t...Continue Reading

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Citations

Aug 17, 2020·Journal of Magnetic Resonance Imaging : JMRI·I-Lun ShihTiffany Ting-Fang Shih
Oct 31, 2020·Frontiers in Oncology·Nghi Co NguyenBalasubramanya Rangaswamy
Jul 28, 2020·Journal of Nuclear Medicine Technology·Nghi C NguyenBalasubramanya Rangaswamy
Oct 9, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Shadi A EsfahaniOnofrio A Catalano

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Software Mentioned

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