Cervical cancer: cytological cervical screening in Iceland and implications of HPV vaccines

Cytopathology : Official Journal of the British Society for Clinical Cytology
K Sigurdsson

Abstract

This paper reviews the Icelandic experience regarding the age-specific effectiveness, optimal targeted age range and intervals in cervical cancer screening and the screening implications of the HPV16/18 vaccines. The background material is based on data from a screening programme with centralized records dating back to 1964, as well as from population-based studies on the distribution of oncogenic HPV types in cancer and histologically verified CIN2-3 lesions and from the Icelandic arm of the Future II trial with Gardasil. The findings confirm significant increased rates in the screened population of CIN2-3, stage IA (microinvasive) cancer since 1979, mainly in the age group 20-34 years. These lesions start to accumulate within 3 years of a normal smear. Studies on the distribution of HPV types indicate that the marketed vaccines could lower the incidence of cancer and CIN2-3 by about 67% and 53%, respectively, after taking into account reported cross-protection. About 65% of women below 25 years of age had lesions related to the non-vaccine types and after the last normal smear these cases accumulated at the same frequency as cases with vaccine-included types. Cases with combined vaccine and non-vaccine types accumulated at a ...Continue Reading

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Citations

Jun 30, 2011·CytoJournal·Songlin ZhangFleurette Abreo
Jul 22, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·A Farnsworth
Nov 10, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·A Herbert
Sep 2, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Chao-Yuan HuangChang-Yao Hsieh
Jan 17, 2012·Cytopathology : Official Journal of the British Society for Clinical Cytology·R M Austin, C Zhao
Jan 22, 2013·Cytopathology : Official Journal of the British Society for Clinical Cytology·K Sigurdsson
Dec 14, 2011·Vaccine·Bente Braad SanderElsebeth Lynge

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