Cervical cancer in pregnancy: Analysis of the literature and innovative approaches

Journal of Cellular Physiology
Anna Myriam PerronePierandrea De Iaco

Abstract

Cervical cancer is one of the most common gynecological malignancies diagnosed during pregnancy although, fortunately, it is a rare event. In majority of cases, the management of cervical cancer in pregnant women is not different from nonpregnant women and prognosis seems not compromised by pregnancy. The association between cancer and pregnancy appears to be a significant challenge for women and specialists and the decisions about therapy must be individualized and taken by a multidisciplinary team. This review is focused on cervical cancer in pregnancy. The aim is to discuss the diagnosis, potential biomarkers and molecular aspects, therapeutic approaches, and prognosis from intraepithelial cervical neoplasia to invasive cervical cancer (early and advanced stages) in different gestational ages. We provide an overview of the current literature regarding the treatment strategies of concurrent pregnancy and cervical cancer cases and we propose some clinical advices to help clinicians to manage this condition. A mention about the effects of the conservative therapy (as conization) on fertility, the human papillomavirus vaccine in pregnant women and our center's experience with obstetrical and oncological outcomes are reported.

References

Mar 1, 1994·Ophthalmology·M Hope-RossC A Puliafito
Sep 1, 1996·British Journal of Obstetrics and Gynaecology·P L GiacaloneB Hedon
Aug 28, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·W van VlietH Boonstra
Feb 13, 2001·Gynecologic Oncology·H R MaranaS Bighetti
Oct 12, 2001·Annals of the New York Academy of Sciences·W T Creasman
Feb 22, 2002·Paediatric and Perinatal Epidemiology·Paola Astolfi, Laura A Zonta
Jul 20, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Evangelos ParaskevaidisDimitrios E Lolis
Dec 4, 2003·Cancer Letters·Andreas WidschwendterChristian Marth
May 4, 2004·The Lancet Oncology·Elyce Cardonick, Audrey Iacobucci
Dec 18, 2004·Journal of Cellular Physiology·Minalini LakshmanSerge Jothy
Feb 26, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chengen XuW Dwayne Lawrence
Dec 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·George Pentheroudakis, Nicholas Pavlidis
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S CaluwaertsF Amant
Oct 5, 2006·Obstetrics and Gynecology·László UngárGiuseppe Del Priore
Dec 13, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yves BenhaimPhilippe Morice
May 31, 2007·Nature Clinical Practice. Oncology·Amer KaramChristine H Holschneider
Oct 2, 2007·American Journal of Obstetrics and Gynecology·Innocenza PalaiaPierluigi Benedetti Panici
Jan 19, 2008·Gynecologic Oncology·Souhail AlouiniPatrice Mathevet
Feb 22, 2008·Gynecologic Oncology·Tetsuro YahataKenichi Tanaka
Feb 23, 2008·Cancer Treatment Reviews·David PeregMichael Lishner
Jul 1, 2008·American Journal of Obstetrics and Gynecology·Mark I HunterBradley J Monk
Apr 28, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Angela BoydCharlie Gourley
Aug 8, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Larry K PickeringUNKNOWN Infectious Diseases Society of America
Aug 26, 2009·International Journal of Clinical Oncology·Shin-ichi IshiokaTsuyoshi Saito
Nov 3, 2009·Journal of Fish Diseases·N G H TaylorK Way
Dec 23, 2009·Clinical Biochemistry·Łukasz KruszynaPaweł P Jagodziński
Apr 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth C SmythDesmond N Carney
Jun 5, 2010·American Journal of Obstetrics and Gynecology·Amanda N FaderKathleen N Moore
Jun 22, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ates KaratekeOzgur Aydin Tosun
Sep 18, 2010·Acta Obstetricia Et Gynecologica Scandinavica·Kristel Van CalsterenFrédéric Amant
Nov 13, 2010·Oncology·Simone MarnitzMaurie Markman
Nov 16, 2010·Surgical Oncology·Corinne BézuSerge Uzan
Mar 12, 2011·Journal of Perinatal Medicine·Malgorzata LanowskaSimone Marnitz
Feb 3, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S IslamR Howells
Feb 14, 2012·Lancet·Philippe MoriceChristine Haie-Meder

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Citations

Dec 4, 2019·Journal of Adolescent and Young Adult Oncology·Emanuela RabaiottiMassimo Candiani
Jan 9, 2020·Journal of Cellular Physiology·Federica TomaoPierluigi Benedetti Panici
Apr 3, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A PucharE Darai
Mar 22, 2020·Cancers·Marta Justyna KoziełAgnieszka Wanda Piastowska-Ciesielska
Mar 26, 2021·The Journal of Obstetrics and Gynaecology Research·Motoki Endo
Aug 14, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Victor N ChilakaJustin C Konje

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