Cervical cancer in young women in Taiwan: prognosis is independent of papillomavirus or tumor cell type

Gynecologic Oncology
Y C YangC P Crum

Abstract

The objective of this study was to address the hypotheses that younger patients with cervical cancer have a uniquely worse clinical outcome and/or are more likely to have adverse tumor cell types or specific human papillomaviruses (HPV). Cases of stage Ib-IIa cervical cancer among women 35 years of age or younger (82) and over 35 (54) were analyzed and compared with respect to the following: (1) histologic type (squamous vs nonsquamous), (2) human papillomavirus (HPV) type via polymerase chain reaction, and (3) clinical parameters, including tumor size, nodal metastases, and recurrence/persistence. Patients 35 years of age or younger had a survival similar (71.2% vs 72.4%) to that of older women from the same institution. In the younger group, outcome was not correlated with the presence or absence of HPV or HPV type. Nonsquamous carcinomas, including adenocarcinoma and small cell carcinoma, were strongly associated with HPV18, were more prevalent in the younger group, and had a slightly higher risk of recurrence/persistence; however, these differences were not significant and 71% of the recurrences were squamous cell carcinomas. Thus, in young Taiwanese women with stage Ib-IIa cervical cancer, the majority of deaths cannot be ...Continue Reading

Citations

Apr 4, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H PilchP G Knapstein
Sep 14, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M GraflundM Karlsson
Jun 17, 2010·American Journal of Clinical Pathology·Elin S AgostonChristopher P Crum
Dec 2, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Chih-Hsiang ChangGuang-Yuh Hwang
May 1, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Y-P BaoUNKNOWN ACCPAB members
Apr 28, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ming-Shien YenCheng-Yang Chou
Jan 31, 2003·British Journal of Cancer·G M CliffordS Franceschi
May 11, 2019·Journal of Gynecologic Oncology·Diama Bhadra ValeLuiz Carlos Zeferino

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