Cervical cancer treatment costs and cost-effectiveness analysis of human papillomavirus vaccination in Vietnam: a PRIME modeling study

BMC Health Services Research
Hoang Van MinhMark Jit

Abstract

Cervical cancer is currently the leading cause of cancer mortality among women in South Vietnam and the second leading cause of cancer mortality in North Vietnam. Human papillomavirus (HPV) vaccination has the potential to substantially decrease this burden. The World Health Organization (WHO) recommends that a cost-effectiveness analysis of HPV vaccination is conducted before nationwide introduction. The Papillomavirus Rapid Interface for Modeling and Economics (PRIME) model was used to evaluate the cost-effectiveness of HPV vaccine introduction. A costing study based on expert panel discussions, interviews and hospital case note reviews was conducted to explore the cost of cervical cancer care. The cost of cervical cancer treatment ranged from US$368 - 11400 depending on the type of hospital and treatment involved. Under Gavi-negotiated prices of US$4.55, HPV vaccination is likely to be very cost-effective with an incremental cost per disability-adjusted life year (DALY) averted in the range US$780 - 1120. However, under list prices for Cervarix and Gardasil in Vietnam, the incremental cost per DALY averted for HPV vaccination can exceed US$8000. HPV vaccine introduction appears to be economically attractive only if Vietnam i...Continue Reading

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Citations

Jul 20, 2019·Cancer Control : Journal of the Moffitt Cancer Center·Tung PhamMinh Hoang
Jun 24, 2020·Human Vaccines & Immunotherapeutics·Suthira TaychakhoonavudhNathorn Chaiyakunapruk
Jul 1, 2020·PharmacoEconomics·Allison PortnoyNicolas A Menzies
Apr 8, 2020·BMC Public Health·Stephanie StephensRobin Crawford
Jul 28, 2020·International Journal of Public Health·Saba AbidiPuneeta Ajmera
May 27, 2017·British Dental Journal·P CullinghamM N Pemberton
Dec 31, 2020·International Journal of Environmental Research and Public Health·Binh Thang TranJin-Kyoung Oh

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Software Mentioned

GAVI
Excel
PRIME
GLOBOCAN

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