Cervical carcinomas with serous-like papillary and micropapillary components: illustrating the heterogeneity of primary cervical carcinomas.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Richard Wing-Cheuk WongPhilip P C Ip

Abstract

Recent changes in the classification of cervical adenocarcinomas have re-categorized serous carcinoma as potentially nonexistent. However, clinical and pathological profiles of cervical adenocarcinomas with serous-like morphological features have not been systematically evaluated using the latest taxonomy and biomarkers. We studied 14 cases of primary cervical carcinomas with serous-like morphologies (papillary and micropapillary patterns). None of these cases exhibited evidence of serous carcinoma involving the upper tracts. Patient ages ranged between 34 and 86 years, most presented with abnormal uterine bleeding. Histologically, ten cases were classified as human papillomavirus (HPV)-associated carcinomas (eight usual-type endocervical adenocarcinomas and two adenosquamous carcinomas), of which six exhibited a papillary pattern and four had a micropapillary pattern. The four remaining cases were HPV-independent gastric-type adenocarcinomas, which displayed a papillary pattern in one case and a micropapillary pattern in three others. All ten HPV-associated carcinomas displayed block positive p16 and wild-type p53 by immunohistochemistry, with nine of them confirmed by HPV testing. Two of the four gastric-type adenocarcinomas ...Continue Reading

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Citations

Feb 12, 2021·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Isabel Alvarado-CabreroAnais Malpica

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Methods Mentioned

BETA
hysterectomy
biopsies
dissection
dissections

Software Mentioned

ClinVar
Torrent Suite
Ion Reporter

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