Cervical cord area measurement using volumetric brain magnetic resonance imaging in multiple sclerosis

Multiple Sclerosis and Related Disorders
Zheng LiuD T Chard

Abstract

In multiple sclerosis (MS), recent work suggests that cervical cord atrophy is more consistently correlated with physical disability than brain white matter lesion load and atrophy. Although spinal cord imaging has not been routinely obtained in many clinical trial and research studies, brain volumetric imaging usually has and includes the upper cervical cord. Using volumetric T1-weighted brain images, we investigated cross-sectional area measures in the uppermost cervical cord and compared them with areas at the standard C2/3 level. Using T1-weighted brain scans from 13 controls and 37 people with MS, and an active surface technique, cross-sectional area was measured over 5mm and 1mm cord segments at C2/3, below the level of odontoid peg, and 2cm and 2.5cm below the pons. Brain volume was also measured. Cord area measurements were most reliable in a 5mm segment 2.5cm below the pons (inter-rater coefficient of variation 1.5%, intraclass correlation coefficient 0.99). Cord area at this level correlated more with that at C2/3 area than with brain volume (r=0.811 with C2/3, r=0.502 with brain volume). Whereas the standard C2/3 level is often not within the field of view on brain images, the level 2.5cm below the pons usually is, a...Continue Reading

References

Jun 4, 1999·Brain : a Journal of Neurology·G R CutterE Willoughby
Jun 17, 2008·AJNR. American Journal of Neuroradiology·Z LiptakC R G Guttmann
Jun 25, 2010·Journal of Magnetic Resonance Imaging : JMRI·Declan T ChardClaudia A M Wheeler-Kingshott
Aug 17, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·U BonatiD T Chard
Oct 30, 2010·Journal of Magnetic Resonance Imaging : JMRI·Patrick A B FreundNikolaus Weiskopf
Mar 31, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Adam B CohenRohit Bakshi
May 2, 2013·Journal of Magnetic Resonance Imaging : JMRI·Hugh KearneyDavid H Miller
Jul 3, 2013·Multiple Sclerosis : Clinical and Laboratory Research·H KearneyD T Chard
Apr 1, 2013·Multiple Sclerosis and Related Disorders·H KearneyD H Miller

❮ Previous
Next ❯

Citations

May 27, 2015·Nature Reviews. Neurology·Hugh KearneyOlga Ciccarelli
Jul 18, 2016·Neuroimaging Clinics of North America·Susan I BlaserGrace Yoon
Jun 16, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nico PapinuttoUNKNOWN North American Imaging in Multiple Sclerosis Cooperative(NAIMS)
May 22, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Charidimos TsagkasKatrin Parmar
Oct 19, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Matteo PardiniMaria Pia Sormani
Aug 14, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Courtney CasserlyJiwon Oh
May 2, 2019·Therapeutic Advances in Neurological Disorders·Marcello MocciaOlga Ciccarelli
Feb 23, 2020·Frontiers in Cellular Neuroscience·Roberta Maria LorenziClaudia A M Gandini Wheeler-Kingshott
Jul 12, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Maria Pia Sormani, Matteo Pardini
Jul 10, 2018·European Radiology Experimental·Niccolò PiaggioClaudia Caponnetto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.