Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection.

The Journal of Infectious Diseases
Taylor B PostonXiaojing Zheng

Abstract

Chlamydia trachomatis can cause reproductive morbidities after ascending to the upper genital tract of women, and repeated infection can lead to worse disease. Data related to protective immune responses at the cervical mucosa that could limit chlamydial infection to the cervix and/or prevent reinfection inform vaccine approaches and biomarkers of risk. We measured 48 cytokines in cervical secretions from women having chlamydial cervical infection alone (n = 92) or both cervical and endometrial infection (n = 68). Univariable regression identified cytokines associated with differential odds of endometrial infection and reinfection risk, and multivariable stepwise regression identified cytokine ratios associated with differential risk. Elevated interleukin (IL) 15/CXCL10 (odds ratio [OR], 0.55 [95% confidence interval {CI}, .37-.78]), IL-16/tumor necrosis factor-α (OR, 0.66 [95% CI, .45-.93]), and CXCL14/IL-17A (OR, 0.73 [95% CI, .54-.97]) cytokine ratios were significantly (P ≤ .05) associated with decreased odds of endometrial infection. A higher Flt-3L/IL-14 ratio was significantly (P = .001) associated with a decreased risk of reinfection (hazard ratio, 0.71 [95% CI, .58-.88]). Cytokines involved in humoral, type I interfero...Continue Reading

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Citations

Oct 21, 2019·Immunology·Leticia MoninVictoria Male
Mar 5, 2020·Frontiers in Genetics·Wujuan ZhongXiaojing Zheng
Oct 23, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clare E GyorkeUma M Nagarajan
Jan 15, 2021·Sexually Transmitted Infections·Kevin J H JanssenNicole H T M Dukers-Muijrers
Mar 9, 2021·Expert Review of Vaccines·Luis M de la MazaSukumar Pal
Mar 28, 2021·Vaccine·Sam M Murray, Paul F McKay
May 4, 2021·Immunologic Research·Christian SelingerSamuel Alizon
Jun 8, 2021·Frontiers in Immunology·Wenjing XiangZhou Zhou

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