Cervical dystonia: Normal auditory mismatch negativity and abnormal somatosensory mismatch negativity

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Jui-Cheng ChenMark J Edwards

Abstract

Previous electrophysiological and psychophysical tests have suggested that somatosensory integration is abnormal in dystonia. Here, we hypothesised that this abnormality could relate to a more general deficit in pre-attentive error/deviant detection in patients with dystonia. We therefore tested patients with dystonia and healthy subjects using a mismatch negativity paradigm (MMN), where evoked potentials generated in response to a standard repeated stimulus are subtracted from the responses to a rare "odd ball" stimulus. We assessed MMN for somatosensory and auditory stimuli in patients with cervical dystonia and healthy age matched controls. We found a significant group ∗ oddball type interaction effect (F (1, 34) = 4.5, p = 0.04, ρI = 0.63). A follow up independent t-test for sMMN data, showed a smaller sMMN amplitude in dystonic patients compared to controls (mean difference control-dystonia: -1.0 µV ± 0.3, p < 0.00, t = -3.1). However the amplitude of aMMN did not differ between groups (mean difference control-dystonia: -0.2 µV ± 0.2, p = 0.24, t = -1.2). We found a positive correlation between somatosensory MMN and somatosensory temporal discrimination threshold. These results suggest that pre-attentive error/deviant dete...Continue Reading

Citations

Feb 17, 2021·Journal of Neural Transmission·Petr KaňovskýMartin Bareš

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