Cervical fluid cytokines in pregnant women: Relation to vaginal wet mount findings and polymorphonuclear leukocyte counts

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Dane B Nenadić, Milos D Pavlović

Abstract

The purpose of the study was to measure and compare concentrations of IFN-gamma, IL-8, IL-10 and IL-12 in cervical fluids of pregnant women with normal and pathologic microscopic findings of vaginal wet mount. Vaginal samples were obtained from 100 pregnant women (22-32 weeks of gestation) without signs and symptoms of preterm labour (PTL), selected on the basis of the microscopic examination of vaginal wet mounts. Cytokine (IFN-gamma, IL-8, IL-10 and IL-12) concentrations were measured in cervical fluids by an enzyme-linked immunosorbent assay. The cytokines were found in cervical fluids of the majority of pregnant women, with IFN-gamma and IL-8 detected in all samples. Concentrations of IL-8 were significantly higher in pregnant women with pathologic findings on vaginal wet mount, including elevated polymorphonuclear (PMN) cell counts. A significant correlation between microscopic findings and cervical fluid IL-8 concentrations may make vaginal wet mount microscopy a useful tool for identification of patients with cervicovaginal inflammation, which is considered a risk factor for spontaneous preterm delivery.

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Citations

Jul 19, 2011·ISRN Obstetrics and Gynecology·Sebastián GaliñanesBeatriz Perazzi
Jan 27, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P Vieira-BaptistaG Donders
Jan 17, 2016·American Journal of Reproductive Immunology : AJRI·Joziani BeghiniAna Katherine Gonçalves
Oct 1, 2015·The Journal of Obstetrics and Gynaecology Research·Won Joon SeongTae Bon Koo
May 17, 2014·American Journal of Reproductive Immunology : AJRI·Caroline Mitchell, Jeanne Marrazzo
Jul 19, 2011·American Journal of Obstetrics and Gynecology·Nardhy Gomez-LopezFelipe Vadillo-Ortega
Apr 22, 2015·Current Infectious Disease Reports·Gilbert G G DondersGert Bellen
Jun 4, 2010·Journal of Leukocyte Biology·Nardhy Gomez-LopezDavid M Olson
May 16, 2017·Research in Microbiology·Gilbert G G DondersPedro Vieira-Baptista

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