Cervical intraepithelial neoplasia grade 3 lesions can regress

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Ane Cecilie MunkJ P A Baak

Abstract

Up to 30% of cervical intraepithelial grades 2-3 (CIN2-3) lesions regress, but some believe that "regression" is due to "curative" punch biopsies. If this is true, CIN2-3 in the resection margins of the biopsies would be associated with more frequent "persistent" CIN2-3. If, however, immunology-related regression exists, regression would increase with increasing biopsy-cone interval. In 61 punch biopsies diagnosed as CIN3 at careful review by two independent gynaecological pathologists, CIN3 in the resection margins and duration of the biopsy-cone interval was evaluated in relation to CIN2-3-or-not in the cones (again after independent review by expert pathologists). 10 of 61 (16%) patients with CIN3 showed CIN1 or less in the follow-up cones. CIN3-or-not in the resection margins, size of the lesion in the punch biopsy, and presence or absence of CIN2-3 in the cones were not correlated with regression-or-not. However, the number of cones without CIN2-3 increased with longer biopsy-cone interval, 5% in patients with a punch-cone biopsy interval under 9 weeks and 38%> or =9 weeks (p<0.001). These results favour the hypothesis that CIN3 can regress, and do not support the "curative punch biopsy" theory.

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Citations

Feb 23, 2011·Archives of Gynecology and Obstetrics·Adriana Bittencourt Campaner, Fernanda Araujo Cardoso
Mar 23, 2013·Journal of Lower Genital Tract Disease·Nermin KocSelçuk Ayas
Jun 20, 2013·Expert Opinion on Medical Diagnostics·Rogier J N T M LitjensArnold-Jan Kruse
Dec 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·E KudelaJ Danko
Apr 7, 2011·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Charlotte E MooringRebecca M N Kimble
Apr 24, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Renata B Simões, Adriana B Campaner
Nov 22, 2015·BMC Infectious Diseases·Melodi MotamediReinhard von Wasielewski
Jan 19, 2017·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Oscar R Fajardo-RamírezHugo A Barrera-Saldaña
Mar 16, 2018·Journal of Lower Genital Tract Disease·Liv Reidun TverelvFinn Egil Skjeldestad
Jan 10, 2019·Oxidative Medicine and Cellular Longevity·Monia OrcianiAndrea Ciavattini
Sep 18, 2021·American Journal of Obstetrics and Gynecology·Peter H SykesLynn Sadler

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