Cervical laser vaporization for women with cervical intraepithelial neoplasia-3

Japanese Journal of Clinical Oncology
Chisa ShimadaHidenori Kato

Abstract

This study evaluated outcomes of laser vaporization of the cervix for women with cervical intraepithelial neoplasia (CIN)-3. We retrospectively reviewed 161 consecutive patients with CIN3 who were treated with cervical laser vaporization between January 2008 and December 2012. At each follow-up visit, histologically confirmed CIN2, CIN3 and invasive carcinoma were defined as treatment failures, as were high-grade squamous intraepithelial lesion (HSIL) or atypical squamous cells that cannot exclude HSIL with subsequent treatment or lost to follow-up. Primary endpoints included long-term follow-up (at least 5 years of regular hospital visits) and treatment failure rate. Treatment failure rates were estimated by the Kaplan-Meier method. Patients' median age was 31 years old. Median follow-up period was 67 months (interquartile range: 52-74 months). Over 5 years, 70.8% continued their follow-up visits, but significantly more patients aged ≥35 years did so (86.4%) than did those aged ≤34 years (61.8%, P = 0.0009). Treatment failure was observed in 14 (8.7%) patients, 1 of whom progressed to invasive cancer (0.6%). Cumulative treatment failure rates were 1-year: 5.1%, 2-year: 6.4% and 5-year: 9.5%. Among patients who suffered treatme...Continue Reading

References

Apr 1, 1985·British Journal of Obstetrics and Gynaecology·J A JordanT Wade-Evans
Apr 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A G Ostör
Feb 26, 1999·Journal of the National Cancer Institute·P HolowatyT To
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G. K. ChewH. C. Kitchener
Oct 8, 2003·Gynecologic Oncology·Maria Grazia FallaniMauro Marchionni
May 6, 2004·JAMA : the Journal of the American Medical Association·Lynn SadlerLesley McCowan
Nov 9, 2004·Lancet·Anna-Barbara MoscickiTeresa M Darragh
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
May 25, 2005·Archives of Gynecology and Obstetrics·Ganesh AcharyaJan Martin Maltau
May 14, 2009·Journal of the National Cancer Institute·Joy MelnikowAndrew Coldman
Aug 19, 2010·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Margaret R E McCredieRonald W Jones
Aug 25, 2010·International Journal of Cancer. Journal International Du Cancer·Koji MatsumotoUNKNOWN Japan HPV And Cervical Cancer Study Group
Mar 3, 2012·BMJ : British Medical Journal·Bengt AndraePär Sparén
May 3, 2013·Obstetrics and Gynecology·L Stewart MassadUNKNOWN 2012 ASCCP Consensus Guidelines Conference
Aug 17, 2016·The Journal of Obstetrics and Gynaecology Research·Tasuku MariyaTsuyoshi Saito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC
Diede L LoopikJames R Bentley
© 2022 Meta ULC. All rights reserved