Cervical mucus antibodies against human papillomavirus type 16, 18, and 33 capsids in relation to presence of viral DNA.

Journal of Clinical Microbiology
Z WangJ Dillner

Abstract

To investigate whether cervical mucus antibodies against human papillomavirus (HPV) capsids are associated with the detection of HPV DNA or HPV-related cytological diagnoses, 611 samples of cervical secretions from 359 women referred to a colposcopy clinic were tested by an enzyme-linked immunosorbent assay for the presence of immunoglobulin A (IgA) antibodies against HPV capsids of HPV type 16, 18, or 33 and for the presence of cervical HPV DNA by PCR. Among subjects with at least one cervical sample positive for HPV type 16 (HPV-16) DNA, 28.1% also had at least one HPV-16 IgA-positive cervical sample (odds ratio [OR] = 2.9; P = 0.0003). IgA to HPV-18 was also more common among HPV-18 DNA-positive subjects (OR = 3.1; P = 0.0325) and IgA to HPV-33 was more common among HPV-33 DNA-positive subjects (OR = 4.2; P = 0.0023). Cervical IgA antibodies to HPV-16 were also more common among patients with cervical intraepithelial neoplasia, particularly among patients with cervical intraepithelial neoplasia grade I (P < 0.0005). The data indicate that an HPV type-restricted IgA antibody response against HPV capsids is detectable in cervical mucus and is associated with a concomitant cervical HPV infection.

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Citations

Jun 18, 1999·Reviews in Medical Virology·J DillnerJ Schiller
Oct 16, 2003·Journal of the National Cancer Institute·Joseph J CarterDenise A Galloway
Feb 26, 2010·The Journal of General Virology·Helena FaustJoakim Dillner
Apr 4, 2020·Expert Review of Anti-infective Therapy·Ralph-Sydney Mboumba BouassaLaurent Bélec
Dec 20, 2007·The Journal of General Virology·Raeda Z RizkMichael Pawlita
Apr 4, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M Y TjiongN Van Der Vange
Mar 14, 2000·Seminars in Cancer Biology·J Dillner
Jul 17, 1998·Clinical and Diagnostic Laboratory Immunology·A HildesheimP A Crowley-Nowick

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