Cervical mucus removal prior to intrauterine insemination: a randomized trial

BJOG : an International Journal of Obstetrics and Gynaecology
Mohammad A MaherN Elkhouly

Abstract

To detect if removing the cervical mucus before performing intrauterine insemination (IUI) could improve pregnancy outcomes in patients with unexplained infertility. Prospective randomized study. An Egyptian University Hospital. Seven hundred and fourteen couples with unexplained infertility who underwent intrauterine insemination (IUI) with or without cervical mucus removal. Using computer-generated numbers, patients were randomly allocated to cervical-mucus-removal (removed from both internal and external os) or non-mucus-removal groups. Only participants were blinded as to group assignment. The clinical pregnancy rate. Of 714 IUI patients between November 2014 and March 2017, 361 were in the mucus removal group, and 353 in the non-mucus-removal group. Difficult catheterization was encountered in 17 cases out of 666 (2.6%) 12 in the cervical-mucus-removal group and five in the non-mucus-removal group). A total of 666 IUI cycles were completed while 48 were either cancelled or lost in their follow-up. The clinical pregnancy rate was significantly higher in the mucus-removal group [31.0% (n = 112)] than in the non-mucus-removal group [21.8% (n = 77); P = 0.005]. Ovarian hyperstimulation developed in 33 (4.6%) cases: 18 cervical...Continue Reading

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Citations

Nov 24, 2018·Expert Opinion on Therapeutic Targets·Vishwaraj SontakeSatish K Madala
May 16, 2020·The Journal of Obstetrics and Gynaecology Research·Ilknur Col MadendagCigdem Karakukcu

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