PMID: 2097334Jan 1, 1990Paper

Cervical ripening of the rat in dependence on endocrine milieu; effects of antigestagens

Journal of Perinatal Medicine
B Stiemer, W Elger

Abstract

The circumstances which cause the ripening of the cervix during the initial phase of parturition are still unexplored. In addition, complications during labour such as cervical dystocia still necessitate cesarian section. Therefore we examined the biomechanical alterations of the cervix during the last trimester of pregnancy. We developed a special method to measure dilatation and resistance of the rat cervix. After testing several substances, the antigestagen Mifepristone turned out to be most effective in causing cervical softening. Further investigations with light and scanning electron microscopy showed an increase of collagen and a possible loosening of collagen fibers after antigestagen treatment. Therefore it might be possible to use Mifepristone, perhaps in combination with a prostaglandin to promote cervical ripening when certain obstetric problems arise.

References

Oct 15, 1979·American Journal of Obstetrics and Gynecology·K von MaillotH Greiling
Jan 1, 1987·American Journal of Obstetrics and Gynecology·T MinamotoY Nagai
Nov 1, 1986·Journal of Steroid Biochemistry·W ElgerR Rohde
May 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W A Shannon, S I Roth
Nov 15, 1983·American Journal of Obstetrics and Gynecology·N UldbjergU Ulmsten
Nov 1, 1980·Journal of Mathematical Biology·M Notohara, T Shiga
Nov 1, 1981·Journal of Reproduction and Fertility·M Hollingsworth, S Gallimore
Feb 1, 1962·The Journal of Physiology·R D HARKNESS, M A NIGHTINGALE
Oct 1, 1959·The Journal of Physiology·M L HARKNESS, R D HARKNESS

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Citations

Jan 7, 1998·Fertility and Sterility·D K Mahajan, S N London
Sep 28, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Roberto Romero
Apr 8, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S S HassanUNKNOWN PREGNANT Trial
Jan 27, 2005·American Journal of Obstetrics and Gynecology·Edward K ChienKelley Clark
May 2, 2006·American Journal of Obstetrics and Gynecology·Kelley ClarkEdward K Chien
Jun 12, 1995·Annals of the New York Academy of Sciences·A UlmannL Silvestre

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