Cervical spinal cord MTR histogram analysis in multiple sclerosis using a 3D acquisition and a B-spline active surface segmentation technique

Magnetic Resonance Imaging
S J HickmanG J Barker

Abstract

The application of a three-dimensional magnetization transfer (MT) sequence and B-spline active surface segmentation method to produce MT histograms of the cervical spinal cord in a pilot study of controls and multiple sclerosis (MS) patients is presented. Subjects' cervical spinal cords were imaged with (a) a volume-acquired inversion-prepared fast spoiled gradient echo sequence and (b) a volume-acquired noninversion-prepared fast spoiled gradient echo MT sequence. The images were segmented using the B spline active surface technique and MT histograms were produced from the MT images. The method was sensitive enough to detect differences between seven MS patients and 10 controls in mean MT ratio (42.4 pu versus 44.0 pu, p = 0.03) and peak location (45.2 versus 46.8, p = 0.03). The spinal cord volumes obtained from the two sequences were associated with each other (parameter estimate 0.972, 95% confidence intervals 0.742, 1.202, p < 0.001).

References

Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·O CoulonS R Arridge

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Citations

Jan 5, 2016·Magma·Benjamin De LeenerVirginie Callot
Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Christopher R TenchCris S Constantinescu
Jan 18, 2014·Journal of Magnetic Resonance Imaging : JMRI·Mohamed-Mounir El MendiliHabib Benali
Apr 29, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Shahrukh MallikDavid H Miller
Mar 10, 2015·Lancet Neurology·Achim GassUNKNOWN MAGNIMS Study Group
Oct 28, 2016·Scientific Reports·Ferran PradosSebastien Ourselin
Mar 7, 2020·Expert Review of Neurotherapeutics·Maria A RoccaMassimo Filippi
Apr 22, 2018·Current Treatment Options in Neurology·Tim SinneckerRegina Schlaeger
May 2, 2018·European Radiology·Charidimos TsagkasArne Fischmann

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