Cervical spine abnormalities associated with Down syndrome

International Orthopaedics
Fawzi Elhami AliEmad Y Esbaita

Abstract

Atlantoaxial instability (AAI) affects 10-20% of individuals with Down syndrome (DS). The condition is mostly asymptomatic and diagnosed on radiography by an enlarged anterior atlanto-odontoid distance. Symptomatic AAI, which affects 1-2% of individuals with DS, manifests with spinal cord compression. Cervical spondylosis, which is common in DS, also has the potential for cord damage but it has received less attention because paediatric populations were mostly studied. Forty-four Kuwaiti subjects with DS, whose ages were > or = 15 years, were evaluated clinically and radiographically. Lateral neck radiographs were taken in the neutral and flexion positions. Asymptomatic AAI was diagnosed in eight subjects (18%) and congenital anomalies of C1-2 were found in five (12%). Five patients had AAI in flexion only while three patients had it in both views. Three patients with AAI had odontoid anomalies contributing to the condition. When assessing AAI, the posterior atlanto-odontoid distance has to be considered because it indicates the space available for the cord. Cervical spondylosis was noted in 16 (36%) subjects. Degenerative changes increased with age, occurred earlier than in the normal population, and affected mostly the lower ...Continue Reading

References

Jan 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E T Crosby, A Lui
Sep 1, 1990·Journal of Pediatric Orthopedics·S M PueschelJ C Pezzullo
Jan 30, 1986·The New England Journal of Medicine·G S Fidone
Jan 1, 1986·Applied Research in Mental Retardation·N Alvarez, L Rubin
Dec 1, 1988·Archives of Disease in Childhood·S ElliottR A Whitelaw
Nov 1, 1988·Clinical Radiology·B JagjivanG Hosking
Jul 1, 1966·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·W Martel, J M Tishler
Nov 1, 1984·Journal of Pediatric Orthopedics·S M PueschelM J Goldberg
Feb 1, 1981·Pediatric Radiology·S M PueschelJ C Pezzullo
Feb 1, 1995·Archives of Disease in Childhood·R E MortonS Elliott
Sep 1, 1993·Archives of Disease in Childhood·M J CremersJ van Gijn
Feb 1, 1994·Archives of Otolaryngology--head & Neck Surgery·E H Harley, M D Collins
Feb 24, 2001·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·P J AllisonD Faulks

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Citations

Oct 31, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Amro Al-Habib, Ahmed AlAqeel
Apr 17, 2014·Pediatric Radiology·Rupa Radhakrishnan, Alexander J Towbin
Feb 18, 2014·World Neurosurgery·Marcelo El-KhouriMarcelo Riberto
Apr 16, 2016·The Indian Journal of Radiology & Imaging·Nishchint JainSurya N Bhaskar
Aug 21, 2013·Developmental Disabilities Research Reviews·Warren B Zigman
May 8, 2014·World Neurosurgery·Konstantinos Margetis, Edward C Benzel
May 8, 2014·World Neurosurgery·Rishi Wadhwa, Praveen V Mummaneni
Nov 30, 2010·Pain·Nanda de Knegt, Erik Scherder
Nov 26, 2015·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Ashokan ArumugamNagarani Shanmugam
Oct 16, 2015·Research in Developmental Disabilities·Nanda de KnegtErik Scherder
May 21, 2008·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Mari Eli Leonelli de MoraesJulio Cezar de Melo Castilho
Dec 1, 2018·Journal of Neurosurgery. Spine·Ryan C HoflerG Alexander Jones
Jul 12, 2011·Journal of Developmental and Behavioral Pediatrics : JDBP·Katherine J SteingassNancy J Roizen
Jul 17, 2020·Pediatric Annals·Shannon B Liu, Theodore V De Beritto
Dec 31, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Nanda C de KnegtErik J A Scherder
Jan 4, 2020·Acta Paediatrica·Niamh LaganEleanor J Molloy
Aug 12, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Astrid C HengartnerTodd C Hankinson
Nov 30, 2019·BMJ Case Reports·Christopher Shane BunttingSaeed Kohan
Jun 8, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Aaron S McAllisterRupa Radhakrishnan
Jun 11, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Christian Fausch, Christof Röösli
Sep 30, 2021·Journal of Paediatrics and Child Health·Lijiin ZhenDaniel Hook
Jun 8, 2021·Respiration; International Review of Thoracic Diseases·Dirk SchrammUNKNOWN Special Interest Group on Pediatric Bronchoscopy of the Society for Pediatric Pneumology (GPP) and invited Societies involve
Dec 1, 2021·Neurosurgical Review·Guillaume BaucherEnrico Tessitore

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