Cervicovaginal microbiota composition correlates with the acquisition of high-risk human papillomavirus types

International Journal of Cancer. Journal International Du Cancer
Xiaojie HuangKai Wang

Abstract

High-risk (hr) human papillomavirus (HPV) infection is closely associated with the clinical conditions of both squamous intraepithelial lesions (SILs) and cervical carcinoma. However, it remains unclear what factors determine the type of hrHPV infection. Here, we have comprehensively investigated the bacterial composition of the cervicovaginal microbiota of 280 women infected with one type of hrHPV (HPV 16, 52 or 58) by the pyrosequencing of barcoded 16S rRNA genes. Differential microbiota composition was observed among various SIL groups and within the subgroups of each group. This result showed that it is not the microbiota diversity or the common microbiota, but rather agents that are specific to each SIL that might have a positive influence on the acquisition of hrHPV types, independent of abundance. Specifically, a composition of Oribacterium, Lachnobacterium and Thermus in the cervicovaginal microbiota is more likely to be associated with HPV 16, while a composition of Motilibacter in the cervicovaginal microbiota is more likely to be associated with HPV 52, and a composition of Litorilinea and Paludibaculum with a concomitant paucity of L. iners in the cervicovaginal microbiota is more likely to be associated with HPV 58...Continue Reading

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Citations

Jun 27, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·J NorenhagN Brusselaers
Jun 6, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mengying WuChunmei Ying
Mar 3, 2020·Frontiers in Cellular and Infection Microbiology·Cameron KleinPeter C Angeletti
Oct 14, 2020·NPJ Biofilms and Microbiomes·Liqin ChengJuan Du
Nov 19, 2020·Microbial Pathogenesis·Bi QingqingXiaofeng Mu
Apr 19, 2021·BMC Infectious Diseases·Lays Paula Bondi VolpiniLiliana Cruz Spano
Nov 1, 2021·The Journal of Infectious Diseases·Julia Andrade Pessoa MoralesMarcia Guimarães da Silva

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