Cervista HPV assays for fine-needle aspiration specimens are a valid option for human papillomavirus testing in patients with oropharyngeal carcinoma

Cancer Cytopathology
Ming GuoGregg A Staerkel

Abstract

The objectives of this study were to evaluate the validity of Cervista human papillomavirus (HPV) assays in head and neck fine-needle aspiration (FNA) specimens from patients with head and neck squamous carcinomas and to verify that the Cervista assay in FNA specimens is a valid option for determining HPV status in patients with oropharyngeal carcinomas. The authors retrospectively retrieved 64 head and neck FNA specimens from patients who had head and neck squamous carcinoma. The specimens were tested for HPV types 16 and 18 (HPV16/18) and for high-risk (HR) HPV DNA using the Cervista HPV16/18 and HPV HR assays, respectively. The results from those assays were compared with the results from polymerase chain reaction (PCR)-based HPV assays in the same tissues and with the results from HPV in situ hybridization assays/p16 immunostaining in the corresponding primary tumors. In total, 64 FNA specimens were analyzed. The Cervista HPV16/18 and/or HPV HR assays were positive in 48 of 64 specimens (75%), and there was a predominance of HPV16 (42 of 48 specimens; 88%). In the 49 specimens that had PCR-based test results, overall agreement with Cervista assay results was 96% (47 of 49 specimens; κ = 0.883). In the 49 specimens that had ...Continue Reading

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Citations

Sep 9, 2015·Cancer Cytopathology·Martina A BroglieSandro J Stoeckli
Mar 1, 2015·Seminars in Diagnostic Pathology·Justin A BishopWilliam C Faquin
Feb 2, 2015·Seminars in Diagnostic Pathology·Sinchita Roy-Chowdhuri, Savitri Krishnamurthy
Jan 27, 2015·Seminars in Diagnostic Pathology·Marc P Pusztaszeri, William C Faquin
Dec 19, 2017·Archives of Pathology & Laboratory Medicine·James S LewisWilliam C Faquin
Jul 11, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Helena BarrocaPio Zeppa
Jul 31, 2018·The Journal of Pathology. Clinical Research·Kelly Y KimZhong Chen

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