PMID: 8605593Apr 15, 1996Paper

Cesarean deliveries and maternal-infant HIV transmission: results from a prospective study in South Africa

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
L KuhnZ A Stein

Abstract

Data from a prospective study undertaken at an urban hospital in Durban, South Africa, were used to investigate associations between maternal-infant HIV transmission, mode of delivery, and specific circumstances of cesarean deliveries. A total of 141 children of HIV-infected women were followed until the children were 15 months of age to determine their HIV status. supplementary data were collected from obstetric records, masked to the HIV status of the children. In this African and predominantly breast-fed population, infants delivered vaginally were more likely to be infected (39.8% infected) than were infants delivered by cesarean section [22.9% infected; odds ratio (OR), 0.45; 95% confidence interval (CI), 0.20-0.99]. There were no significant differences between cesarean deliveries undertaken following prior rupture of membranes and those undertaken with membranes intact, but numbers for this comparison were small. Singleton cesarean deliveries without concurrent obstetric complications had lower rates of transmission than did vaginal deliveries (OR, 0.20; 95% CI, 0.04-0.94). These results suggest that certain intrapartum events may modify the risk of HIV transmission and highlight the importance of collecting more detaile...Continue Reading

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Citations

Feb 26, 2004·Indian Journal of Pediatrics·Chokechai Rongkavilit, Basim I Asmar
Apr 1, 1999·The New England Journal of Medicine·UNKNOWN International Perinatal HIV GroupR Tuomala
Jun 14, 2002·The New England Journal of Medicine·D Heather Watts
Jan 11, 2000·AIDS·J E EmbreeF A Plummer
Jan 12, 2007·International Anesthesiology Clinics·Samuel C Hughes
May 1, 1997·Oral Diseases·F J Ramos-Gomez
Oct 19, 2010·Indian Journal of Pediatrics·Chokechai Rongkavilit, Basim I Asmar
Aug 25, 2004·Anesthesiology Clinics of North America·Samuel C Hughes
Sep 14, 2007·American Journal of Obstetrics and Gynecology·Denise J JamiesonKenneth L Dominguez
Dec 2, 2009·International Journal of STD & AIDS·S Reid
Dec 19, 2015·Current Opinion in HIV and AIDS·Caroline Pfeifer, Madeleine J Bunders
Dec 24, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J A Jacquez
Aug 8, 2002·Oral Diseases·F Ramos-Gomez

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