Cesarean section due to fetal distress increases the number of stem cells in umbilical cord blood

Transfusion
Gwendolin ManegoldCarolyn Troeger

Abstract

Umbilical cord blood (UCB) can be used as hematopoietic stem cell source for transplantation. The success of a transplantation is highly correlated with the number of total nucleated cells (TNCs) and CD34+ cells in the UCB. Certain obstetric factors increase the yield of stem cells in the UCB. It is necessary to evaluate optimal conditions in labor to decrease the rate of sample rejection due to low cell count. No data exist regarding the difference between primary and secondary Cesarean sections in terms of efficacy of stem cell harvesting. Seventy-nine consecutive UCB units from women who had a Cesarean section between 1997 and 2003 were included. The number of TNCs, CD34+ cells, colony-forming units (CFUs), white blood cells (WBCs), nucleated red blood cells (NRBCs), and the total collection volume were compared between cases with primary and secondary Cesarean section. UCB obtained after a Cesarean section due to fetal distress has significantly higher numbers of TNCs, CD34+ cells, NRBCs, and WBCs compared to elective Cesarean section. Of the cases with secondary Cesarean section due to fetal distress, 67 percent resulted in UCB units with sufficient TNC numbers (> or =80 x 10(7) TNCs) compared to 42 percent of the cases wi...Continue Reading

References

Sep 23, 2000·Baillière's Best Practice & Research. Clinical Haematology·E GluckmanC Chastang
Jun 16, 2001·The New England Journal of Medicine·M J LaughlinJ Kurtzberg
Mar 16, 2002·Transfusion·Rosemary L SparrowMark A Kirkland
Sep 4, 2003·Journal of Perinatal Medicine·Ulrike AufderhaarDaniel V Surbek
Feb 14, 2004·Transfusion·Ryuji NakagawaUNKNOWN Chugoku-Shikoku Cord Blood Bank
Apr 12, 2005·Transfusion·Pekka AroviitaRiitta Kekomäki
Jul 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Giuseppe MoriciMaria R Bonsignore
May 27, 2006·Human Immunology·Pablo Rubinstein
Aug 22, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·V ZanardoD Trevisanuto
Sep 28, 2006·Transfusion·Thomas J GeorgeJohn R Wingard
Mar 16, 2007·British Journal of Haematology·Claudio G BrunsteinJohn E Wagner

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Citations

Jul 27, 2010·Archives of Gynecology and Obstetrics·Gwendolin ManegoldCarolyn Troeger
Jun 24, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sahar M A HassaneinMahmoud M K H Hellal
Jul 3, 2009·Vox Sanguinis·C M Khodabux, A Brand
Sep 16, 2010·Annals of the New York Academy of Sciences·Xiao Yan ZhongWolfgang Holzgreve
Dec 3, 2016·Pediatric Blood & Cancer·Seyed Hadi MousaviMona Ahmadipanah
Feb 26, 2016·Scientific Reports·Gianluigi MazzoccoliRoberto Tarquini
Dec 19, 2019·Cell and Tissue Banking·Isabella Di TullioDario Gregori
Jan 4, 2020·Asian Journal of Transfusion Science·Seyed Hadi MousaviBahareh Abbaspanah
Feb 17, 2021·Archives of Gynecology and Obstetrics·Anna FunkGwendolin Manegold-Brauer
Sep 28, 2021·Zeitschrift für Geburtshilfe und Neonatologie·Patricia Farina-EckhardtGwendolin Manegold-Brauer

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