Cestode strobilation: prediction of developmental genes and pathways.

BMC Genomics
Gabriela Prado PaludoHenrique B Ferreira

Abstract

Cestoda is a class of endoparasitic worms in the flatworm phylum (Platyhelminthes). During the course of their evolution cestodes have evolved some interesting aspects, such as their increased reproductive capacity. In this sense, they have serial repetition of their reproductive organs in the adult stage, which is often associated with external segmentation in a developmental process called strobilation. However, the molecular basis of strobilation is poorly understood. To assess this issue, an evolutionary comparative study among strobilated and non-strobilated flatworm species was conducted to identify genes and proteins related to the strobilation process. We compared the genomic content of 10 parasitic platyhelminth species; five from cestode species, representing strobilated parasitic platyhelminths, and five from trematode species, representing non-strobilated parasitic platyhelminths. This dataset was used to identify 1813 genes with orthologues that are present in all cestode (strobilated) species, but absent from at least one trematode (non-strobilated) species. Development-related genes, along with genes of unknown function (UF), were then selected based on their transcriptional profiles, resulting in a total of 34 g...Continue Reading

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Datasets Mentioned

BETA
E-ERAD-50
GSE59173

Methods Mentioned

BETA
RNA-seq

Software Mentioned

Trimmomatic
ComBat R package
CLUSTAL Omega
InterProScan
PAL2NAL
BLAST
HMMER phmmer
Cytoscape
DESeq2
WGCNA R package

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