Cetirizine and hydrocortisone differentially regulate ICAM-1 expression and chemokine release in cultured human keratinocytes

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Cristina AlbanesiGiampiero Girolomoni

Abstract

Cetirizine is a H1 histamine antagonist which possesses anti-inflammatory properties through inhibition of leucocyte recruitment and activation, and reduction of ICAM-1 expression on mucosal epithelial cells. No studies have addressed the potential anti-inflammatory activities of cetirizine on skin keratinocytes. Cetirizine and hydrocortisone were compared in their capacity to counteract human keratinocytes activation by IFNgamma. In particular, expression of immuno-modulatory membrane molecules and chemokine release have been examined. Keratinocyte cultures established from normal skin of healthy donors were activated by IFNgamma (100-500 U/mL) in the absence or presence of cetirizine (10(-3)-10(3) microM) or hydrocortisone (10(-3)-10(2) microM), and tested for expression of ICAM-1, HLA-DR, MHC class I and CD40 as well as for release of RANTES, IL-8, macrophage chemotactic protein-1 (MCP-1) and granulocyte macrophage-colony stimulating factor (GM-CSF). Cetirizine at high concentrations (10(2)-10(3) microM) markedly inhibited IFNgamma-induced expression of membrane ICAM-1, HLA-DR and up-regulation of MHC class I, but had no effect on CD40 expression. In contrast, hydrocortisone (10(2) microM) enhanced IFNgamma-induced membrane ...Continue Reading

References

Jul 1, 1992·Experimental Dermatology·A BudnikJ Krutmann
May 1, 1989·The Journal of Allergy and Clinical Immunology·E N CharlesworthL M Lichtenstein
May 1, 1995·The Journal of Allergy and Clinical Immunology·T JinquanK Thestrup-Pedersen
Mar 1, 1995·The Journal of Allergy and Clinical Immunology·F E SimonsK J Simons
Aug 1, 1993·Immunopharmacology and Immunotoxicology·F B AielloS K Durum
Jan 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G M Walsh
Sep 1, 1993·The Journal of Investigative Dermatology·G GirolomoniP R Bergstresser
Jan 1, 1993·Annual Review of Immunology·M A Farrar, R D Schreiber
Apr 1, 1996·The Journal of Investigative Dermatology·J LiM H Thornhill
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Oct 1, 1996·European Journal of Immunology·R W DenfeldJ C Simon

❮ Previous
Next ❯

Citations

Oct 2, 2004·Journal of Physiology and Biochemistry·V Alfaro
Dec 29, 2007·Clinical Reviews in Allergy & Immunology·Liang-Shiou Ou, Jing-Long Huang
Oct 8, 1999·Journal of Dermatological Science·H Koizumi, A Ohkawara
Jun 14, 2012·Natural Product Research·Alessandro VendittiArmandodoriano Bianco
Jul 19, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Haijun YangYuxin Zheng
Dec 14, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R ArnoldW König
Dec 14, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Hayashi, S Hashimoto
Oct 10, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J T SchroederW Kreutner
Feb 6, 2007·Journal of Fluency Disorders·Jacqueline K Wittke-ThompsonNancy J Cox
Jan 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T ShimizuH Shimizu
Nov 24, 2007·Experimental Dermatology·Yoshiki TokuraKenji Kabashima
Oct 24, 2008·Journal of Pharmacological Sciences·Fadia MahmoudLadislav Novotney
Dec 22, 2011·American Journal of Rhinology & Allergy·Angela P BautistaMiguel J Lanz
Mar 28, 2003·Journal of Leukocyte Biology·Andrea M Woltman, Cees van Kooten
Oct 21, 2000·Endocrine Reviews·A Slominski, J Wortsman
Feb 20, 2003·International Journal of Immunopathology and Pharmacology·G. BrunoS. Bracchitta
Jan 9, 2008·International Journal of Immunopathology and Pharmacology·M B Di SciascioM Di Gioacchino
Feb 24, 2004·Drugs·Monique P CurranCaroline M Perry
Apr 14, 2021·Dermatology and Therapy·Chang-Yu Hsieh, Tsen-Fang Tsai
Nov 18, 2000·The Journal of Allergy and Clinical Immunology·G D Marshall
Mar 11, 2000·The Journal of Laboratory and Clinical Medicine·S J McFaulV M Villa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.