Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus.

Auris, Nasus, Larynx
Satoshi KoyamaHiromi Takeuchi

Abstract

Basaloid squamous cell carcinoma (BSCC), a histologically distinctive variant of squamous cell carcinoma comprising basal cell carcinoma and squamous cell carcinoma, is aggressive and shows a poor prognosis because of frequent lymph node invasion and distant metastases. To date few articles regarding chemotherapy for metastatic disease have been reported, thus feasible chemotherapy is not well established. Cetuximab is a monoclonal antibody for epithelial growth factor receptor (EGFR), which has great efficacy for head and neck squamous cell carcinoma due to EGFR signaling pathway blockage. Because BSCC also highly expresses EGFR, cetuximab may be effective for BSCC. We report here a first case of recurrent BSCC in the ethmoid sinus with intracranial extension treated with cetuximab-based chemotherapy, which revealed great response in a 40-year-old man. Positron emission tomography (PET) revealed no lymph node or distant metastasis. The patient underwent chemoradiotherapy 66 Gy in 33 fractions with triweekly 100 mg/m2 cisplatin. However, 12 weeks after treatment completion PET revealed a residual tumor at the primary cancer site. Combination therapy with weekly paclitaxel and cetuximab was started, and complete response was obs...Continue Reading

References

Sep 13, 2000·The Laryngoscope·A F PaulinoA G Huvos
Aug 19, 2004·ANZ Journal of Surgery·Michael JeffordIan D Davis
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Larry H KalishElizabeth A Musgrove
Jul 31, 2007·World Journal of Gastroenterology : WJG·Yoshihiro ShibataShuji Nakano
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
Aug 15, 2009·Journal of the National Comprehensive Cancer Network : JNCCN·Barbara BurtnessSharon Spencer
Aug 26, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R HittUNKNOWN Spanish Head and Neck Cancer Cooperative Group (TTCC)

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Citations

Jun 22, 2021·Cancer Biomarkers : Section a of Disease Markers·Jenilson da SilvaSilma Pereira

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