Cetuximab and Taxol co-modified collagen scaffolds show combination effects for the repair of acute spinal cord injury

Biomaterials Science
Caixia FanJianwu Dai

Abstract

Injury-activated endogenous neural stem cells (NSCs) in the spinal cord have promising therapeutic applications for rebuilding the neuronal relays after spinal cord injury (SCI) because of their lack of immune-rejection following exogenous cell transplantation. However, these NSCs rarely differentiate into neurons and the damaged axonal regenerative ability is drastically reduced due to the adverse SCI microenvironment. Cetuximab, an EGFR signaling antagonist, has demonstrated the ability of promoting NSC differentiation into neurons. Taxol, in addition to stabilizing microtubules, has shown potential for enhancing axonal regeneration and reducing scar formation after SCI. In this study, we further verified the combined therapeutic effects of Cetuximab and Taxol on inhibition of scar deposition and promotion of neuronal differentiation, axonal outgrowth and functional recovery in a rat severe SCI model. A linear orderly collagen scaffold modified with Cetuximab and Taxol was grafted into the SCI site after the complete removal of 4 mm of spinal tissue. The results showed that the combined functional scaffold implantation significantly increased neural regeneration to reconnect the neural network. Moreover, scaffold transplantat...Continue Reading

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Citations

Feb 25, 2020·EMBO Molecular Medicine·Jarred M Griffin, Frank Bradke
Jun 14, 2019·Stem Cells International·Sumei Liu, Zhiguo Chen
Nov 19, 2020·Stem Cells International·Liansheng GaoGao Chen
Apr 9, 2021·International Journal of Pharmaceutics·Amina T Mneimneh, Mohammed M Mehanna

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Methods Mentioned

BETA
scanning electron microscopy
transmission electron microscopy

Software Mentioned

SPSS

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