Cetuximab-modified silica nanoparticle loaded with ICG for tumor-targeted combinational therapy of breast cancer

Drug Delivery
Xiaoxue ZhangJun Yang

Abstract

Combinational therapy is usually considered as a preferable approach for effective cancer therapy. Especially, combinational chemo and photothermal therapy is of particular interest due to its high flexibility as well as efficiency. In this article, we the silica nanoparticles (SLN) were surface conjugated with Cetuximab (Cet-SLN) to target epidermal growth factor receptor (EGFR), a common receptor that usually observed to overexpress in multiple breast cancers. Moreover, the high drug loading capacity of Cet-SLN was employed to encapsulate photothermal agent indocyanine green (ICG) to finally fabricate a versatile drug delivery system (DDS) able to co-deliver Cet and ICG (Cet-SLN/ICG) for combinational chemo-photothermal therapy of breast cancer. The obtained results clearly demonstrated that Cet-SLN/ICG was well-dispersed nanoparticles with preferable stability under physiological condition. Furthermore, due to the conjugation of Cet, Cet-SLN/ICG could target EGFR which overexpress in MCF-7 cells. Most importantly, both in vitro and in vivo results suggested that compared with Cet or ICG alone, the Cet-SLN/ICG showed superior anticancer efficacy. In conclusion, Cet-SLN/ICG could be a potential platform for effective combinati...Continue Reading

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Citations

Oct 4, 2019·Current Drug Metabolism·Siyu GuanJihui Tang
Jul 14, 2020·Experimental Dermatology·Anca SindrilaruDiana Crisan
May 14, 2020·Nanomaterials·Miguel Gisbert-Garzarán, María Vallet-Regí
Apr 14, 2020·Nanotechnology, Science and Applications·Nasrul WathoniMuchtaridi Muchtaridi
Feb 15, 2020·The Journal of International Medical Research·Xiaojun SunGuobiao Yang
Sep 3, 2020·Nanomaterials·Sarkar Siddique, James C L Chow
Jun 9, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jingwei ZhangJieyuan Zhang
Feb 26, 2021·International Journal of Nanomedicine·Zehra EdisMunazza Ijaz
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Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayeskanta MohantyIn-Kyu Park
Jul 6, 2021·International Journal of Biological Macromolecules·Jamileh KadkhodaAyuob Aghanejad

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Methods Mentioned

BETA
xenograft
fluorescence microscopy

Software Mentioned

ZEWTON

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