Cetuximab Plus Chemotherapy versus Chemotherapy Alone in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Cost-Effectiveness Analysis

Cancer Management and Research
Yitian Lang, Deshi Dong

Abstract

The EXTREME clinical trial revealed that cetuximab plus chemotherapy improved the overall survival time of patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) versus chemotherapy alone. The current study examined the cost-effectiveness of cetuximab plus chemotherapy compared with chemotherapy alone in HNSCC patients from the perspective of China. A partitioned survival model was implemented for R/M HNSCC patients. Survival information was derived from the CHANGE-2 trial. The model was designed as a ten-year time horizon, a 3-week cycle, and a 3% discount rate for costs and utilities. An incremental cost-effectiveness ratio (ICER) value is less than $30,201/quality-adjusted life-year (QALY) was considered cost-effective in China. We analyzed the uncertainty by performing one-way and probabilistic sensitivity analyses. In the base-case analysis, we found that the ICER of cetuximab plus chemotherapy compared with chemotherapy alone is $172,702/QALY. The results of one-way sensitivity analysis and probabilistic analysis showed that the fluctuations of each variable in its ranges do not cause ICERs to reach acceptable thresholds. The current observations suggested that treatment with cetuximab plu...Continue Reading

References

Dec 23, 2003·Cost Effectiveness and Resource Allocation : C/E·Raymond HutubessyTessa Tan-Torres Edejer
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
Jun 20, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·N van der LindenC A Uyl-de Groot
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Sep 30, 2017·Journal of Medical Economics·Ye ZhaoJin-Hui Tian

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Citations

Jul 14, 2021·Journal of Translational Medicine·Andrea BotticelliPaolo Marchetti
Aug 27, 2021·Frontiers in Immunology·Andrea BotticelliPaolo Marchetti

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Clinical Trials Mentioned

NCT02383966

Software Mentioned

R package “ digitize
R

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