Cetuximab versus bevacizumab in metastatic colorectal cancer: a comparative effectiveness study

Journal of Cancer Research and Clinical Oncology
Rui Pedro MarquesAna Paula Martins

Abstract

Uncertainty exists regarding comparative effectiveness of cetuximab versus bevacizumab in metastatic colorectal cancer (mCRC). We conducted a retrospective head-to-head multi-cohort study comparing clinical outcomes from both antibodies METHODS: Cohorts were defined by treatment line and subgroups by (K)RAS status and tumour sidedness. Among other outcomes, we estimated and compared response rates, progression-free (PFS) and overall survival (OS). Between January 2010 and April 2018, 311 patients were included. Except for (K)RAS mutation status, baseline characteristics were balanced across treatment groups. In the full analysis of first and second-line cohorts, PFS (first-line: HR = 0.85; 95% CI 0.64 to 1.13; P = 0.26; second-line: HR = 1.16; 95% CI 0.74 to 1.83; P = 0.51) and OS (first-line: HR = 0.83; 95% CI 0.61 to 1.15; P = 0.26; second-line: HR = 0.88; 95% CI 0.56 to 1.38; P = 0.58) were similar between bevacizumab and cetuximab arms. In subgroup analyses of first-line therapy, we found a survival difference favouring bevacizumab in right-sided tumours (PFS: HR = 0.52; 95% CI 0.29 to 0.93; P = 0.025; OS: HR = 0.60; 95% CI 0.32 to 1.12; P = 0.11), but not in left-sided (HR = 1.04; 95% CI 0.75 to 1.46; P = 0.81; OS: HR = 0....Continue Reading

References

Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jun 21, 2014·Annals of Surgical Treatment and Research·Kyeong Woon ChoiHyucksang Lee
Aug 12, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominik P ModestVolker Heinemann
Sep 17, 2015·Current Treatment Options in Oncology·Elena ElezJosep Tabernero
Oct 13, 2015·Nature Medicine·Justin GuinneySabine Tejpar
Jul 7, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemD Arnold
Dec 3, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Julian Walter HolchVolker Heinemann
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 10, 2018·Cancer Cell·Rona YaegerNikolaus Schultz
Jun 25, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kaitlyn K H GoeyMiriam Koopman
Mar 14, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federico InnocentiOmar Kabbarah
May 3, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Heinz-Josef LenzOmar Kabbarah
Jul 19, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Zi-Xian WangRui-Hua Xu

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Citations

Jan 29, 2021·Applied Health Economics and Health Policy·Wânia Cristina da SilvaEli Iola Gurgel Andrade
Mar 22, 2021·Clinical Colorectal Cancer·Ioannis A Voutsadakis

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