CFD modeling and image analysis of exhaled aerosols due to a growing bronchial tumor: towards non-invasive diagnosis and treatment of respiratory obstructive diseases

Theranostics
Jinxiang XiShengyu Wang

Abstract

Diagnosis and prognosis of tumorigenesis are generally performed with CT, PET, or biopsy. Such methods are accurate, but have the limitations of high cost and posing additional health risks to patients. In this study, we introduce an alternative computer aided diagnostic tool that can locate malignant sites caused by tumorigenesis in a non-invasive and low-cost way. Our hypothesis is that exhaled aerosol distribution is unique to lung structure and is sensitive to airway structure variations. With appropriate approaches, it is possible to locate the disease site, determine the disease severity, and subsequently formulate a targeted drug delivery plan to treat the disease. This study numerically evaluated the feasibility of the proposed breath test in an image-based lung model with varying pathological stages of a bronchial squamous tumor. Large eddy simulations and a Lagrangian tracking approach were used to model respiratory airflows and aerosol dynamics. Respirations of tracer aerosols of 1 µm at a flow rate of 20 L/min were simulated, with the distributions of exhaled aerosols recorded on a filter at the mouth exit. Aerosol patterns were quantified with multiple analytical techniques such as concentration disparity, spatial ...Continue Reading

Citations

Jun 11, 2016·Computers in Biology and Medicine·Robert KoprowskiEdward Wylęgała
May 5, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jinxiang XiRichard A Corley
Nov 23, 2018·Expert Opinion on Drug Delivery·P Worth LongestMichael Hindle
Mar 16, 2019·Pharmaceutics·Tânia F G G CovaSandra C C Nunes
Jan 21, 2020·Journal of Biomechanical Engineering·Jamasp AzarnooshAbdollah Arabshahi
Feb 26, 2019·Drug Delivery·Mohammad K D ManshadiAmir Sanati-Nezhad
Jul 7, 2020·Computer Methods and Programs in Biomedicine·W M FaizalRoziana Mohd Razi

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Methods Mentioned

BETA
biopsy

Software Mentioned

ANSYS ICEM CFD
SAS
ImageJ

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