CFLAR is a critical regulator of cerebral ischaemia-reperfusion injury through regulating inflammation and endoplasmic reticulum (ER) stress

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Wang XiaohongQinqin Fan

Abstract

Stroke is a leading cause of mortality and disability globally. Cerebral ischaemia-reperfusion (I/R) injury is characterized by significant inflammation and extensive cell death. Multiple signaling pathways play essential roles in the process, and identifying the unclear crucial regulators of these pathways may provide promising targets for treatment. CASP8 and FADD-like apoptosis regulator (CFLAR) is expressed in multiple organs to regulate inflammation. Here, we reported that CFLAR expression was markedly reduced in brain samples of mice with middle cerebral artery occlusion (MCAO) stroke. Furthermore, CFLAR knockdown markedly elevated the neurological deficit, brain water content and the infarct volume. In addition, significantly promoted inflammation and endoplasmic reticulum (ER) stress was detected in brain tissues of mice after MCAO, as evidenced by the promoted expression of p-IκBα, p-nuclear factor (NF)-κB (p65), glucose-regulated protein 78 (GRP78), PKR-like ER kinase (PERK), activating transcription factor-6 (ATF-6) and cleaved Caspase-12. Notably, MCAO-induced cerebral I/R injury was markedly alleviated in mice over-expressing CFLAR through suppressing inflammation and ER stress. Furthermore, our in vitro results in...Continue Reading

References

Oct 3, 2002·Nature Reviews. Immunology·Qiutang Li, Inder M Verma
Aug 29, 2006·Surgical Neurology·Judy HuangRafael J Tamargo
Aug 5, 2008·Neuroscience·D A Ridder, M Schwaninger
Dec 10, 2008·Stroke; a Journal of Cerebral Circulation·Peter S Vosler, Jun Chen
Dec 10, 2008·Stroke; a Journal of Cerebral Circulation·Myron D Ginsberg
Apr 18, 2009·American Journal of Respiratory Cell and Molecular Biology·Seung-Ick ChaDavid W H Riches
Nov 19, 2009·Journal of Translational Medicine·Shaheen E LakhanMagdalena Hofer
Oct 20, 2010·Annals of the New York Academy of Sciences·Olivier A Harari, James K Liao
Jun 28, 2011·Journal of Hepatology·Jörn M SchattenbergMarcus Schuchmann
Jul 21, 2011·Nature Immunology·Andrea OeckinghausSankar Ghosh
Dec 29, 2011·Basic Research in Cardiology·Jinfeng XiaoHongliang Li
Nov 22, 2012·Journal of Visualized Experiments : JoVE·Estelle RousseletNabil G Seidah
Jan 6, 2016·Journal of Cellular Biochemistry·Manish K GuptaArthur M Feldman
Jan 18, 2016·Frontiers in Neuroendocrinology·April AuGillian Einstein
Jun 24, 2017·Cell Death and Differentiation·Morgane LouessardBenoit D Roussel
Mar 28, 2018·Ageing Research Reviews·Jianjun LvYang Yang
Sep 15, 2018·Theranostics·Shuai JiangChunhu Gu
Sep 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yayun LiuYong Chen

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