CFTR structure and function: is there a role in the kidney?

Biophysics Reviews
J Souza-Menezes, Marcelo M Morales

Abstract

Cystic fibrosis (CF) is a lethal autosomal recessive genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR). Mutations in the CFTR gene may result in a defective protein processing that leads to changes in function and regulation of this chloride channel. Despite of the expression of CFTR in the kidney, patients with CF do not present major renal dysfunction, but it is known that both the urinary excretion of proteins and renal capacity to concentrate and dilute urine are altered in these patients. CFTR mRNA is expressed in all nephron segments of rat and human, and this abundance is more prominent in renal cortex and outer medulla renal areas. CFTR protein was detected in apical surface of both proximal and distal tubules of rat kidney but not in the outer medullary collecting ducts. Studies have demonstrated that CFTR does not only transport Cl(-) but also ATP. ATP transport by CFTR could be involved in the control of other ion transporters such as Na(+) (ENaC) and K(+) (renal outer medullary potassium) channels, especially in TAL and CCD. In the kidney, CFTR also might be involved in the endocytosis of low-molecular-weight proteins by proximal tubules. This review is focused on the CFTR func...Continue Reading

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Citations

Sep 25, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xuan YangXiaoyun He
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