cGMP production in bacteria.

Molecular and Cellular Biochemistry
Jürgen U Linder

Abstract

Production of cGMP in bacteria has been studied since the early 1970s. From the beginning on it proved to be a challenging topic. In Escherichia coli the cGMP levels were two orders of magnitude lower than the corresponding cAMP levels. Furthermore, no specific cGMP receptor protein was identified in the bacterium and a physiological role of cGMP in the bacterium was not substantiated. Consequently in 1977, compelling evidence was given that cGMP is a by-product of E. coli adenylate cyclase in vivo. This may be the reason why also work on cGMP in other bacteria like Bacillus licheniformis and Caulobacter crescentus was not pursued any further. However, recent study on cGMP and guanylate cyclase in the cyanobacterium Synechocysis PCC 6803 brought cGMP signaling in bacteria back to attention. In Synechocystis cGMP levels are of similar magnitude as those of cAMP and deletion of the cya2 gene markedly reduced the amount of cGMP without affecting cAMP. A few months ago the Cya2 gene product has been biochemically and structurally characterized. It behaves as a specific guanylate cyclase in vitro and a single amino acid substitution transforms the enzyme into a specific adenylate cyclase. These data point toward the existence of a t...Continue Reading

References

Nov 6, 1974·Biochemical and Biophysical Research Communications·I C SunO M Rosen
Feb 25, 1972·Biochemical and Biophysical Research Communications·V L Clark, R W Bernlohr
Nov 1, 1970·Archives of Biochemistry and Biophysics·M Tao, A Huberman
Jun 15, 1984·Biochemical and Biophysical Research Communications·N B BhatnagarT A Venkitasubramanian
Jan 1, 1994·Progress in Nucleic Acid Research and Molecular Biology·O Bârzu, A Danchin
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·C L TuckerJ B Hurley
Jun 20, 1998·The Journal of Biological Chemistry·R K SunaharaA G Gilman
Jun 13, 2000·Journal of Bacteriology·J A Ochoa De AldaJ Houmard
Jun 18, 2002·Infection and Immunity·Shane Petersen, Glenn M Young
Jul 12, 2002·The EMBO Journal·Tobias KanacherJoachim E Schultz
Oct 25, 2003·Cellular Signalling·Jürgen U Linder, Joachim E Schultz
Jun 9, 2004·European Journal of Biochemistry·Jürgen U LinderJoachim E Schultz
Jan 29, 2005·The EMBO Journal·Sangita C SinhaJürgen U Linder
Feb 3, 2005·FEMS Microbiology Letters·Young Ran KimJoon Haeng Rhee
Oct 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Annika RauchClemens Steegborn

❮ Previous
Next ❯

Citations

Jun 11, 2014·Acta Crystallographica. Section D, Biological Crystallography·Seung-Hyeon SeokBong-Jin Lee
Nov 12, 2013·BMC Biotechnology·Janet I WheelerHelen R Irving
Jan 25, 2011·Molecular Microbiology·Mark Gomelsky
Feb 2, 2011·Environmental Microbiology·Paola MilanesioVíctor de Lorenzo
Aug 22, 2013·The EMBO Journal·Mark Gomelsky, Michael Y Galperin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.