CGRP and nitric oxide of neuronal origin and their involvement in neurogenic vasodilatation in rat skin microvasculature

British Journal of Pharmacology
M MerhiZ Khalil

Abstract

1. Sensory nerves are important for the initiation of neurogenic inflammation and tissue repair. Both calcitonin gene-related peptide (CGRP) and nitric oxide (NO) have been implicated in neurogenic vasodilatation and inflammatory responses. 2. A blister model in the rat hind footpad was used as a site to induce neurogenic vasodilatation in response to antidromic electrical stimulation of the sciatic nerve. Blood flux was monitored with a laser Doppler flow monitor. 3. The quantitative contributions of CGRP and NO to vasodilatation were examined by use of the CGRP receptor antagonist CGRP8-37 and NO synthase inhibitors 7-nitroindazole (7-NI), 3-bromo 7-NI and N(G)-nitro L-arginine methyl ester (L-NAME). The potential modulatory role of endothelin was examined by use of the ET(A) receptor antagonist BQ-123. 4. CGRP8-37 (10 microM) was perfused over the blister base before nerve stimulation and continuously throughout the post-stimulation period, resulting in a significant reduction (41%) in the blood flux vascular response. 5. Pretreatment with the specific neuronal NO synthase inhibitors, 7-NI and 3-bromo 7-NI (10 mg kg(-1), i.v.), and of the non-specific L-NAME (100 microM), resulted in significant inhibition of the blood flux ...Continue Reading

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Dec 1, 1992·Acta Physiologica Scandinavica·P Delay-GoyetJ M Lundberg
Jan 1, 1992·Neuron·D S Bredt, S H Snyder
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Feb 1, 1990·The Journal of Clinical Investigation·C Boulanger, T F Lüscher
Jul 7, 1988·European Journal of Pharmacology·Z KhalilR D Helme
Aug 1, 1987·British Journal of Pharmacology·G C GraceT J Martin
Apr 4, 1994·Brain Research·Z KhalilR D Helme
May 1, 1994·The European Journal of Neuroscience·R MorrisJ Garthwaite
Feb 1, 1993·Pain·S T Meller, G F Gebhart
Jan 1, 1996·American Journal of Nephrology·E R Levin

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Citations

Feb 13, 1999·Progress in Neurobiology·M J Millan
Aug 7, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Bereha KhodrZeinab Khalil
Mar 19, 2002·The Journal of Physiology·David HarrisMichael D Randall
Oct 27, 2015·Journal of Pharmacological Sciences·Yingzi ZhaoSusan W S Leung
Dec 24, 2014·Acta Physiologica·R D GransteinW Ding
May 29, 2004·Neuropharmacology·Geoffrey Andrew LambertAlessandro Stefano Zagami
Feb 22, 2011·Brain, Behavior, and Immunity·Jing HuangRichard D Granstein
Oct 24, 2014·Pflügers Archiv : European journal of physiology·Noboru Toda, Tomio Okamura
Mar 25, 2010·Journal of Cellular Physiology·M AimettiA Graziano
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura

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