CGRP in the trigeminal nucleus, spinal cord and hypothalamus: effect of gonadal steroids

Neuropeptides
S MoussaoulB Kerdelhué

Abstract

Calcitonin gene-related peptide (CGRP) contents were assayed in cervical spinal cord, trigeminal nucleus and hypothalamus throughout the estrous cycle and in male and ovariectomized rats. In the trigeminal nucleus, neither testosterone nor 17 beta-estradiol seem to affect CGRP accumulation, but progesterone seems to decrease it. In the cervical spinal cord, ovarian steroids seem to decrease CGRP while testosterone does not seem to influence it. In the hypothalamus, CGRP was only detectable in the male rat suggesting a positive effect of testosterone. It had marked circadian rhythm. In conclusion, CGRP content appears to be affected by gonadal steroids in the hypothalamus, the cervical spinal cord and the trigeminal nucleus in the rat.

References


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Citations

Jan 21, 2004·Current Pain and Headache Reports·Dawn A Marcus
Nov 1, 2008·Current Pain and Headache Reports·Vincent T Martin
Jun 7, 2005·Neuropeptides·Veena PuriNancy E J Berman
Aug 5, 2000·The Journal of Steroid Biochemistry and Molecular Biology·F LabombardaA F De Nicola
Mar 13, 2014·PloS One·Sieneke LabruijereAntoinette MaassenVanDenBrink
Jun 3, 2011·Headache·Saurabh GuptaNancy E J Berman
Jun 3, 2011·Headache·Hayrunnisa BolayDidem Akcali
Oct 31, 2017·Cephalalgia : an International Journal of Headache·Alejandro Labastida-RamírezAntoinette MaassenVanDenBrink
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Henry C Evrard
Jun 12, 2020·Therapeutic Advances in Neurological Disorders·Anna P AndreouGiorgio Lambru

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