PMID: 8951678Jan 1, 1996Paper

CGRP increases the rate of corneal re-epithelialization in an in vitro whole mount preparation

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
A A Mikulec, D L Tanelian

Abstract

A number of studies have localized CGRP to nerves in the cornea and iris, and it is thought that CGRP, along with other neuropeptides, is involved in pain sensation. It is also possible that CGRP could mediate trophic influences between nerve endings and corneal epithelium. This investigation utilized an in vitro rabbit corneal whole mount preparation to study the effect of topical 2.5 microM CGRP application on epithelial wound healing rates of 5 mm diameter epithelial wounds. CGRP (2.5 microM) was applied topically to 5 mm epithelial wounds at 0, 4, 16, 20, 24, 28, 40, 44, 48, 52, 56, 64, 68, and 72 hours after wounding and healing was visualized with fluorescein. CGRP was found to increase the epithelial wound healing rate by 25%, from 51 +/- 3 microns/hr for the control corneas, to 64 +/- 2 microns/hr for CGRP-treated corneas (mean +/- standard error, n = 10). Histological examination of the corneas following healing showed that the epithelium of the CGRP-treated corneas healed in a similar manner as in the control corneas. These findings may have clinical utility for the understanding and treatment of corneal and other epithelial wounds.

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Citations

Sep 3, 2013·Experimental Eye Research·Ian D Meng, Masayuki Kurose
Apr 17, 2003·Experimental Eye Research·Linda J MüllerTimo M T Tervo
Feb 12, 2008·The Ocular Surface·Jeanie ChuiMinas T Coroneo
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Jul 29, 2006·Brain Research Reviews·Josef TrogerEduard Schmid
Nov 15, 2016·The Ocular Surface·Francesco SabatinoStefano Bonini
Mar 25, 2017·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Blanka GolebiowskiIsabelle Jalbert
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Nov 25, 2003·Eye·S BoniniA Lambiase
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Jan 28, 2015·Cornea·Young-Chun Lee, Su-Young Kim
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