CGRP mediate the isosorbide-5-mononitrate cardiovascular response in healthy Chinese male volunteers through a XOR-independent pathway

International Journal of Clinical Pharmacology and Therapeutics
Zuoliang LiuRen Guo

Abstract

This study was designed to determine whether xanthine oxidoreductase (XOR) is involved in Isosorbide- 5-mononitrate (IS-5-MN) metabolism, and to elucidate the role of the neuropeptide calcitonin gene-related peptide (CGRP) in the IS-5-MN response. In 15 Chinese volunteers, we observed the relationship between baseline XOR-mRNA expression in peripheral blood mononuclear cells (PBMCs) and the response to 20 mg IS-5-MN. IS-5-MN pharmacokinetics profiles, changes in plasma concentrations of CGRP, and CGRPmRNA expression in PBMCs were assessed in vivo and in vitro. Individuals with a lower baseline XOR-mRNA expression showed lower plasma XOR activity and significantly greater changes in SBP (ΔSBP) after IS-5-MN administration. Individuals with a lower baseline XOR-mRNA expression also showed significantly greater increases in plasma concentrations of CGRP. There were no differences in IS-5-MN AUC between the two groups. IS-5-MN significantly up-regulated the expression of CGRP α- and CGRP β-mRNA in PBMCs, which were not affected by the XOR inhibitor allopurinol. Our study suggests that CGRP may contribute to the response to IS-5 MN in a XOR-independent pathway.

Citations

Feb 4, 2016·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Anup Sunil TamhankarAvanish Saklani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Revue du rhumatisme : maladies des os et des articulations
M S Moukhtar, A Jullienne
Nihon rinsho. Japanese journal of clinical medicine
Hiroshi Takami
Nihon rinsho. Japanese journal of clinical medicine
Yoshifumi Ikeda, Hiroshi Takami
Nihon rinsho. Japanese journal of clinical medicine
Y Ikeda, Hiroshi Takami
© 2022 Meta ULC. All rights reserved