CGRP Receptor Signalling Pathways

Handbook of Experimental Pharmacology
Graeme S Cottrell

Abstract

Calcitonin gene-related peptide (CGRP) is a promiscuous peptide, similar to many other members of the calcitonin family of peptides. The potential of CGRP to act on many different receptors with differing affinities and efficacies makes deciphering the signalling from the CGRP receptor a challenging task for researchers.Although it is not a typical G protein-coupled receptor (GPCR), in that it is composed not just of a GPCR, the CGRP receptor activates many of the same signalling pathways common for other GPCRs. This includes the family of G proteins and a variety of protein kinases and transcription factors. It is now also clear that in addition to the initiation of cell-surface signalling, GPCRs, including the CGRP receptor, also activate distinct signalling pathways as the receptor is trafficking along the endocytic conduit.Given CGRP's characteristic of activating multiple GPCRs, we will first consider the complex of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) as the CGRP receptor. We will discuss the discovery of the CGRP receptor components, the molecular mechanisms controlling its internalization and post-endocytic trafficking (recycling and degradation) and the diverse signa...Continue Reading

Citations

May 22, 2020·Expert Review of Neurotherapeutics·Eleonora De MatteisSimona Sacco
Jul 16, 2020·International Journal of Molecular Sciences·Shirin KahremanyGuy Cohen
Aug 6, 2020·Journal of Pain Research·Lanfranco PellesiMessoud Ashina
Nov 14, 2019·The Journal of Headache and Pain·Jacob C A EdvinssonKristian A Haanes
Nov 27, 2020·Frontiers in Neurology·Darja VisočnikMatija Zupan
Feb 26, 2021·Cephalalgia : an International Journal of Headache·Minoti BhaktaKimberly D Mackenzie
Dec 4, 2020·Physiological Reviews·Christian AalkjærJo G R De Mey
Feb 15, 2020·Journal of Medicinal Chemistry·Gene M DubowchikAlison W Xin
Aug 8, 2021·British Journal of Pharmacology·Flóra GölöncsérBeáta Sperlágh

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