CHA2DS2-VASc score performance to predict stroke after acute decompensated heart failure with and without reduced ejection fraction
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Anat BerkovitchRoy Beinart
Abstract
To validate the utility of CHA2DS2-VASc score to predict the annual risk of stroke in patients admitted with acute heart failure, comparing those with preserved ejection fraction (HF-presEF) and reduced ejection fraction (HF-redEF). We investigated 2922 patients with known atrial fibrillation who were admitted to the Sheba Medical Center for acute decompensated heart failure (HF). Anticoagulation therapy was prescribed based on CHA2DS2-VASc score or physician's discretion. Subjects were divided into four pre-specified groups based on HF type and median CHA2DS2-VASc score: HF-presEF with CHA2DS2-VASc <5(N = 731), HF-presEF with CHA2DS2-VASc ≥5 (N = 1102), HF-redEF with CHA2DS2-VASc <5 (N = 563), and HF-redEF with CHADS2-VASc ≥5 (N = 526). The primary endpoint was an ischaemic stroke at 1 year. Mean age of the study population was 79 ± 11 years, of whom more than half were women. The median CHA2DS2-VASc score for the entire study population was 5.0 (interquartile range 25-75%: 4-6). Stroke rate for the entire study population was 6.6%. Multivariate Cox regression proportional hazards regression analysis revealed that in both HF-redEF and HF-presEF patients, each one-point increment in CHA2DS2-VASc was associated with a correspond...Continue Reading
References
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Sep 19, 1998·Journal of the American College of Cardiology·D L DriesL W Stevenson
Apr 3, 2003·The American Journal of Cardiology·William H Maisel, Lynne Warner Stevenson
May 16, 2006·Journal of the American College of Cardiology·Lars G OlssonUNKNOWN CHARM Investigators
Jul 11, 2006·American Heart Journal·Brandi J WittVéronique L Roger
Mar 18, 2008·Journal of Neurology·Angel OisJaume Roquer
Sep 19, 2009·Chest·Gregory Y H LipHarry J G M Crijns
Jan 17, 2012·European Heart Journal·Leif FribergGregory Y H Lip
Aug 28, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A John CammUNKNOWN Document Reviewers
Mar 5, 2014·Circulation·Rick A NishimuraJames D Thomas
Apr 2, 2014·Journal of the American College of Cardiology·Craig T JanuaryClyde W Yancy
Sep 16, 2014·The American Journal of Medicine·Alanna M ChamberlainVéronique L Roger
Jan 30, 2015·Stroke; a Journal of Cerebral Circulation·Roopinder K SandhuJeff S Healey
Mar 3, 2015·European Journal of Heart Failure·Gregory Y H LipGiuseppe Boriani
Nov 19, 2015·International Journal of Cardiology·Dipak KotechaGregory Y H Lip
Nov 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paulus KirchhofKatja Zeppenfeld
Apr 6, 2017·Stroke; a Journal of Cerebral Circulation·Kasper AdelborgHenrik Toft Sørensen
Aug 23, 2017·International Journal of Cardiology·Si-Hyuck KangDong-Ju Choi
Oct 27, 2017·Heart and Vessels·Yoshihiro SobueYukio Ozaki
Mar 30, 2018·Journal of Cardiac Failure·Jeffrey S BergerMatthew R Weir
May 1, 2018·International Journal of Cardiology·Jolanta M Siller-MatulaUNKNOWN TEAM in AF group