ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques.

BioRxiv : the Preprint Server for Biology
Neeltje van DoremalenVincent J Munster

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in December 20191,2 and is responsible for the COVID-19 pandemic3. Vaccines are an essential countermeasure urgently needed to control the pandemic4. Here, we show that the adenovirus-vectored vaccine ChAdOx1 nCoV-19, encoding the spike protein of SARS-CoV-2, is immunogenic in mice, eliciting a robust humoral and cell-mediated response. This response was not Th2 dominated, as demonstrated by IgG subclass and cytokine expression profiling. A single vaccination with ChAdOx1 nCoV-19 induced a humoral and cellular immune response in rhesus macaques. We observed a significantly reduced viral load in bronchoalveolar lavage fluid and respiratory tract tissue of vaccinated animals challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in vaccinated rhesus macaques. Importantly, no evidence of immune-enhanced disease following viral challenge in vaccinated animals was observed. ChAdOx1 nCoV-19 is currently under investigation in a phase I clinical trial. Safety, immunogenicity and efficacy against symptomatic PCR-positive COVID-19 disease will now be assessed in randomised controlled human clinical trials.

Citations

Jun 6, 2020·Nature Reviews. Immunology·Peter J HotezMaria Elena Bottazzi
Aug 21, 2020·Signal Transduction and Targeted Therapy·Shuaiyao LuXiaozhong Peng
Sep 29, 2020·Frontiers in Immunology·Clarisa B Palatnik-de-Sousa
Jul 1, 2020·Turkish Journal of Biology = Türk Biyoloji Dergisi·Murat TopuzoĞullariSerap Derman
Jul 10, 2020·MSphere·Raúl Gómez RománMelanie Saville
Aug 28, 2020·Frontiers in Immunology·Vibhuti Kumar ShahSamit Chattopadhyay
Sep 24, 2020·Nature·Florian Krammer
Jul 9, 2020·Frontiers in Pharmacology·Colin D FunkAli Ardakani
Jul 28, 2020·International Journal of Molecular Sciences·Alessandra FierabracciPaolo Rossi
Sep 10, 2020·Experimental Hematology & Oncology·Ehtisham Ul HaqJiancheng Guo
Aug 28, 2020·Vaccines·Mohammed A Rohaim, Muhammad Munir
Aug 5, 2020·Human Vaccines & Immunotherapeutics
Sep 24, 2020·Expert Review of Vaccines·Leonard MoiseAnne S De Groot
Jul 15, 2020·Journal of Virology·Gustaf Ahlénrepresenting the OPENCORONA consortia
Aug 26, 2020·Nature Medicine·Kathryn M Edwards
Jun 28, 2020·Journal of Virology·John P Moore, P J Klasse
Oct 8, 2020·Critical Care : the Official Journal of the Critical Care Forum·Salleh N EhaidebAbderrezak Bouchama
Jul 28, 2020·Vaccines·Daniel E Speiser, Martin F Bachmann
Oct 16, 2020·Immunopharmacology and Immunotoxicology·Tushar BaviskarLokesh Kumar Bhatt
Nov 4, 2020·Human Vaccines & Immunotherapeutics·Fiona Russell, Brian Greenwood
Dec 4, 2020·Human Vaccines & Immunotherapeutics·Vipin M Vashishtha, Puneet Kumar
Dec 16, 2020·SLAS Discovery·Dawid MaciorowskiAdinarayana Kunamneni
Dec 23, 2020·Viral Immunology·Minghao DongYu Deng
Jan 5, 2021·Human Vaccines & Immunotherapeutics·Firzan NainuHarapan Harapan
Jan 5, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nikoo Hossein-KhannazerMassoud Vosough
Nov 3, 2020·Canadian Journal of Microbiology·Marina Liu, Xiongbiao Chen
Feb 11, 2021·Vaccines·Shaswath S ChandrasekarAdel M Talaat
Oct 31, 2020·Frontiers in Immunology·Katie L FlanaganSophie Ch Wen
Nov 8, 2020·Pathogens·Akshay KanakanRajesh Pandey
Dec 3, 2020·Canadian Journal of Microbiology·Raquel RussellBrian L Mark
Dec 10, 2020·Vaccines·Azizul Haque, Anudeep B Pant
Feb 16, 2021·Frontiers in Physiology·Miquéias Lopes-PachecoPatricia Rieken Macedo Rocco
Oct 31, 2020·Human Vaccines & Immunotherapeutics·Lifeng LiHuiqing Sun
Oct 31, 2020·Frontiers in Immunology·Jon Hazeldine, Janet M Lord
Nov 17, 2020·Frontiers in Veterinary Science·Roberta Torres de MeloHeriberto Fernandez
Nov 27, 2020·Frontiers in Immunology·Zhihui LiangBingbing Sun
Dec 30, 2020·International Journal of Molecular Sciences·Jung-Hyun Won, Howard Lee
Nov 13, 2020·Frontiers in Pharmacology·Junqing HuangJia-Xu Chen

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.